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A Mouse Model for Vascular Cognitive Impairment and Dementia Based on Needle-guided Asymmetric Bilateral Common Carotid Artery Stenosis
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A Mouse Model for Vascular Cognitive Impairment and Dementia Based on Needle-guided Asymmetric Bilateral Common Carotid Artery Stenosis

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Deep medullary veins: a promising neuroimaging marker for mild cognitive impairment in outpatients

Xiuqi Chen1, Yufan Luo1, Shufan Zhang1,2

  • 1Department of Neurology, Shanghai Fifth People's Hospital, Fudan University, No.801, He Qing Road, Minhang District, Shanghai, China.

BMC Neurology
|January 5, 2023
PubMed
Abstract

Insights

Deep medullary veins (DMV) are linked to mild cognitive impairment (MCI) and cognitive decline. Higher DMV scores in MCI patients correlate with poorer global cognition, memory, attention, and executive function.

Area of Science:

  • Neurology
  • Neuroimaging
  • Cognitive Science

Background:

  • Mild cognitive impairment (MCI) is an age-related condition preceding dementia.
  • Vascular factors play a significant role in the development of MCI.
  • Early detection of MCI is crucial for managing dementia progression.

Purpose of the Study:

  • To investigate the association between deep medullary veins (DMV) and cognitive outcomes in individuals with MCI.
  • To explore the relationship between DMV visibility and various cognitive domains.

Main Methods:

  • A cohort of 73 MCI patients and 32 controls was recruited.
  • Global cognitive function was assessed using the Mini-Mental State Examination and Montreal Cognitive Assessment.
  • Neuropsychological tests measured specific cognitive domains, while MRI evaluated DMV visibility and other neuroimaging markers.

Main Results:

  • The MCI group exhibited significantly higher deep medullary vein (DMV) scores compared to the control group (P=0.009).
  • DMV score was independently associated with MCI (P=0.007).
  • Linear regression revealed a linear relationship between DMV score and global cognition, memory, attention, and executive function, even after adjusting for cerebrovascular risk factors.

Conclusions:

  • Deep medullary vein (DMV) score is an independent predictor of mild cognitive impairment (MCI) onset.
  • DMV score correlates with global cognition, memory, attention, and executive function in outpatient settings.
Keywords:
Deep medullary veinMild cognitive impairmentNeuropsychologic test

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