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Published on: April 28, 2023
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High porosity 3D printed titanium mesh allows better bone regeneration
Rui Ma1,2, Qian Liu2,3, Libo Zhou4
1Department of Dental Implant Centre, Beijing Stomatological Hospital, Capital Medical University, Capital Medical University School of Stomatology, No. 4 Tian Tan Xi Li, Dongcheng District, Beijing, 100050, China.
BMC Oral Health
|January 5, 2023
Summary
High porosity titanium mesh significantly enhanced bone regeneration in beagle dogs, showing superior bone volume and structure compared to low porosity options for treating bone defects.
Area of Science:
- Biomaterials Science
- Regenerative Medicine
- Oral and Maxillofacial Surgery
Background:
- Bone defects present a significant challenge in oral implant surgery, often requiring bone augmentation.
- Insufficient bone mass can compromise the success of dental implants.
Purpose of the Study:
- To compare the bone regeneration efficacy of 3D printed titanium meshes with varying porosities.
- To evaluate the impact of titanium mesh porosity on bone defect repair in a preclinical model.
Main Methods:
- Three-dimensional (3D) printed titanium meshes with low (55%), medium (62%), and high (68%) porosity were implanted into mandibular bone defects in beagle dogs.
- Bone regeneration was assessed using micro-computed tomography (micro-CT) and histological staining at 4, 8, and 12 weeks post-surgery.
Main Results:
- High porosity (HP) titanium mesh demonstrated significantly higher trabecular thickness, number, and bone volume fraction compared to low (LP) and medium (MP) porosity meshes.
- Micro-CT and histological analyses revealed superior bone regeneration in the HP group, with reduced trabecular separation.
- Statistically significant differences (p < 0.05) were observed in bone regeneration parameters between the groups.
Conclusions:
- A 3D printed titanium mesh with high porosity offers advantages for repairing large bone defects.
- Optimizing titanium mesh porosity is crucial for enhancing bone regeneration in oral implantology.
