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Updated: Aug 15, 2025

Pre-clinical Evaluation of Tyrosine Kinase Inhibitors for Treatment of Acute Leukemia

Pre-clinical Evaluation of Tyrosine Kinase Inhibitors for Treatment of Acute Leukemia

Published on: September 18, 2013

Alectinib-induced hemolytic anemia.

Chung-Shien Lee^1,2, Kevin Sullivan²

¹College of Pharmacy and Health Sciences, Department of Clinical Health Professions, St John's University, Queens, NY, USA.

Journal of Oncology Pharmacy Practice : Official Publication of the International Society of Oncology Pharmacy Practitioners

|January 6, 2023

Summary

This summary is machine-generated.

Alectinib, a treatment for anaplastic lymphoma kinase-positive non-small cell lung cancer, can cause hemolytic anemia. This case report provides evidence of this adverse effect, highlighting the need for monitoring.

Keywords:

Alectinib ROS Proto-Oncogene 1 (ROS1)anaplastic lymphoma kinase hemolytic anemia non-small cell lung cancer

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Induction of Alloantigen-specific Anergy in Human Peripheral Blood Mononuclear Cells by Alloantigen Stimulation with Co-stimulatory Signal Blockade

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Published on: March 14, 2011

Area of Science:

Oncology
Pharmacology

Background:

Alectinib is a preferred first-line treatment for anaplastic lymphoma kinase (ALK)-positive non-small cell lung cancer (NSCLC).
Alectinib is known to potentially cause anemia, typically mild.

Observation:

A patient receiving alectinib for ALK-positive NSCLC developed hemolytic anemia.
The patient's hemoglobin levels normalized after dose reduction and eventual discontinuation of alectinib.

Findings:

This case presents objective evidence of alectinib-induced hemolytic anemia.
Hemolytic anemia is a potential adverse effect of alectinib treatment.

Implications:

Clinicians should be aware of the risk of hemolytic anemia in patients treated with alectinib.
Monitoring hemoglobin levels in patients on alectinib is crucial for early detection of anemia.