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Updated: Aug 15, 2025

Prospective, Randomized, and Controlled Study of a Human Umbilical Cord Mesenchymal Stem Cell Injection for Treating Diabetic Foot Ulcers

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A 12-Week Supervised Exercise Therapy Program for Patients with Diabetic Foot Ulcers: Program Development and

Thomas Vedste Aagaard^1,2,3, Kajsa Lindberg⁴, Stig Brorson^3,5

¹Department of Physiotherapy and Occupational Therapy, Holbaek Hospital, Holbaek, Denmark.

The International Journal of Lower Extremity Wounds

|January 6, 2023

Summary

Developing an exercise program for diabetic foot ulcers (DFUs) showed patient relevance but faced recruitment challenges. Future studies need accessible settings for better feasibility.

Keywords:

diabetic foot ulcers health-related quality of life assessments lower extremity wounds wound assessment

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Area of Science:

Podiatry
Exercise Physiology
Diabetology

Background:

Exercise therapy can improve glycaemic control and insulin sensitivity, potentially aiding diabetic foot ulcer (DFU) treatment.
Previous research includes systematic reviews on exercise for DFUs and grounded theory studies on patient concerns regarding physical activity.

Purpose of the Study:

To develop a 12-week exercise therapy program for patients with diabetic foot ulcers (DFUs).
To assess the preliminary feasibility of the program, focusing on inclusion, adherence, and safety.

Main Methods:

Program development integrated existing evidence and stakeholder feedback (doctors, nurses, podiatrists, patients, physical therapists).
The 12-week program combined moderate-intensity aerobic exercise (stationary bike) and resistance training (15-repetition maximum).
Semi-structured interviews were used to gather feedback during the development phase.

Main Results:

Three patients completed the exercise intervention.
Acceptance levels met research criteria, except for recruitment and retention rates.
Patients found the program relevant but desired more guidance and community-based settings.

Conclusions:

The developed exercise therapy program shows promise but requires adjustments for feasibility.
Low recruitment and retention rates limit definitive conclusions on feasibility.
Future intervention studies should consider more accessible community settings for improved participation.