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Related Experiment Video

Updated: Aug 15, 2025

Induction of Maternal Immune Activation in Mice at Mid-gestation Stage with Viral Mimic PolyI:C
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Abnormal maternal behavior in mice lacking phospholipase Cβ1.

Hea-Jin Kim1,2, Jaewon Jang1,3, Hae-Young Koh1,2

  • 1Brain Science Institute (BSI), Korea Institute of Science and Technology (KIST), Seoul, Republic of Korea.

Animal Cells and Systems
|January 6, 2023
PubMed
Summary
This summary is machine-generated.

Phospholipase C beta 1 (PLCβ1) signaling is crucial for maintaining maternal behavior. Knocking out PLCβ1 impairs pup retrieval and survival, highlighting its role beyond the initial maternal response.

Keywords:
Maternal neglectPhospholipase Cβ1maintenance of maternal behaviormaternal motivationmice

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Area of Science:

  • Neuroscience
  • Behavioral Biology
  • Molecular Biology

Background:

  • Maternal behavior involves hormonal and neural changes across distinct phases: preparation, onset, and maintenance.
  • Key signaling pathways, including G-protein-coupled receptors and plasma membrane enzymes like phospholipase C (PLC) β isoforms, regulate maternal actions.

Purpose of the Study:

  • To investigate the role of Phospholipase C beta 1 (PLCβ1) in maternal behavior.
  • To determine the impact of PLCβ1 knockout (KO) on the different phases of maternal care and associated neural mechanisms.

Main Methods:

  • Comparison of maternal behavior between PLCβ1 knockout (KO) and wild-type (WT) dams.
  • Assessment of pup retrieval latency and pup survival rates.
  • Measurement of FosB expression in the nucleus accumbens (NAcc) and medial preoptic area (mPOA).

Main Results:

  • PLCβ1-KO dams showed normal maternal behavior initially but neglected pups after 18 hours postpartum (PPH 18), leading to pup death.
  • Pup retrieval was impaired in PLCβ1-KO dams after PPH 18.
  • FosB expression was reduced in the NAcc of PLCβ1-KO dams, but not in the mPOA.

Conclusions:

  • PLCβ1 signaling is essential for the transition from the onset to the maintenance phase of maternal behavior.
  • The findings implicate PLCβ1 in the NAcc, a region critical for maternal motivation and behavior maintenance.