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Updated: Aug 15, 2025

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Understanding the Dual Roles of CircHIPK3 in Tumorigenesis and Tumor Progression

Zeyu Wei1,2,3, Yijia Shi1,2,3, Changning Xue1,3,4

  • 1NHC Key Laboratory of Carcinogenesis, Hunan Cancer Hospital and The Affiliated Cancer Hospital of Xiangya School of Medicine, Central South University, Changsha, Hunan 410013, China.

Journal of Cancer
|January 6, 2023
PubMed

Insights

Circular HIPK3 (circHIPK3) RNA shows varied expression in tumors, acting as a tumor promoter or inhibitor. Understanding its roles is key for cancer diagnosis and treatment.

Area of Science:

  • Molecular Biology
  • Oncology
  • Genetics

Background:

  • Circular RNAs (circRNAs) are endogenous RNA molecules with a closed-loop structure.
  • circHIPK3, a specific circRNA, is differentially expressed in various cancers.
  • circHIPK3 lacks protein-coding potential but influences tumorigenesis.

Purpose of the Study:

  • To review the differential expression of circHIPK3 in tumors.
  • To elucidate the dual roles (promotion and inhibition) of circHIPK3 in tumorigenesis.
  • To explore the regulatory mechanisms and network of circHIPK3 in cancer.

Main Methods:

  • Literature review of studies on circHIPK3 in various cancers.
  • Analysis of differential expression data.
  • Examination of circHIPK3's function as a miRNA sponge.

Main Results:

  • circHIPK3 exhibits altered expression patterns across different tumor types.
  • circHIPK3 can act as both a tumor promoter and a tumor suppressor.
  • circHIPK3 regulates gene expression by sponging microRNAs (miRNAs).

Conclusions:

  • circHIPK3 plays a significant, context-dependent role in tumor development.
  • circHIPK3 holds potential as a diagnostic biomarker and therapeutic target in oncology.
  • Further research into circHIPK3 mechanisms is crucial for cancer therapy development.
Keywords:
circHIPK3differential expressiondual rolesregulation mechanismtumorigenesis

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