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Critical appraisal on mitochondrial dysfunction in Alzheimer's disease

Faizan Ahmad1, Punya Sachdeva2

  • 1Department of Medical Elementology and Toxicology Jamia Hamdard University Delhi India.

Aging Medicine (Milton (N.S.W))
|January 6, 2023
PubMed

Insights

Alzheimer's disease (AD) involves mitochondrial dysfunction, impacting cognitive decline. Understanding these mechanisms offers new therapeutic targets for this progressive neurodegenerative disorder.

Area of Science:

  • Neurodegenerative Diseases
  • Mitochondrial Biology
  • Alzheimer's Disease Pathogenesis

Background:

  • Alzheimer's disease (AD) is a progressive neurodegenerative disorder causing cognitive impairment.
  • AD is characterized by amyloid plaques and tau proteins.
  • Mitochondrial dysfunction is increasingly recognized as a key factor in AD.

Purpose of the Study:

  • To review mechanisms of mitochondrial dysfunction in Alzheimer's disease.
  • To explore the role of mitochondria in AD pathogenesis.
  • To identify potential therapeutic targets for AD based on mitochondrial pathways.

Main Methods:

  • Literature review of studies on Alzheimer's disease and mitochondrial function.
  • Analysis of mechanisms linking mitochondrial disruption to AD hallmarks.
  • Synthesis of current understanding of mitochondrial pathogenesis in AD.

Main Results:

  • Mitochondrial disruption leads to mitochondrial DNA (mtDNA) dysfunction.
  • Altered calcium (Ca2+) homeostasis is linked to mitochondrial dysfunction in AD.
  • Dysfunctional mitochondria contribute to copper and immune cell issues in AD.

Conclusions:

  • Mitochondrial dysfunction is central to Alzheimer's disease pathogenesis.
  • Understanding these pathways is crucial for developing novel AD therapies.
  • Targeting mitochondrial dysfunction may offer a new era for AD treatment.
Keywords:
Alzheimer's diseasemitochondrial dysfunctionneurodegenerative disease

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