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Prognostic implication of left ventricular hypertrophy regression after antihypertensive therapy in patients with

Hyue Mee Kim1, In-Chang Hwang2,3, Hong-Mi Choi2,3

  • 1Division of Cardiology, Department of Internal Medicine, Chung-Ang University Hospital, Chung-Ang University College of Medicine, Seoul, Republic of Korea.

Frontiers in Cardiovascular Medicine
|January 6, 2023
PubMed

Insights

Left ventricular hypertrophy (LVH) regression in hypertensive patients significantly reduces cardiovascular events. Achieving LVH regression is a key prognostic marker for better outcomes in hypertension management.

Area of Science:

  • Cardiology
  • Hypertension Research
  • Echocardiography

Background:

  • Left ventricular hypertrophy (LVH) is a significant risk factor for cardiovascular mortality in hypertensive patients.
  • The prognostic value of LVH regression following antihypertensive treatment requires further investigation.

Purpose of the Study:

  • To investigate the prognostic implications of left ventricular hypertrophy (LVH) regression in patients with hypertension.
  • To assess the association between LVH regression and cardiovascular outcomes.

Main Methods:

  • Retrospective analysis of patients with hypertension who underwent serial echocardiography.
  • LVH defined by LV mass index (LVMI); regression defined as normalization of LV geometry.
  • Analysis of cardiovascular mortality, heart failure hospitalizations, and vascular events.

Main Results:

  • 44.7% of hypertensive patients had LVH at diagnosis; 30.7% achieved LVH regression.
  • LVH regression was associated with blood pressure reduction.
  • Persistent or new LVH predicted increased cardiovascular mortality and events, particularly heart failure hospitalization.

Conclusions:

  • LVH regression in hypertensive patients is linked to reduced cardiovascular events.
  • LVH regression serves as a valuable prognostic marker in hypertension management.
Abstract

Keywords:
echocardiographyhypertensionhypertensive heart diseaseleft ventricular hypertrophyleft ventricular mass regression

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