Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Biological activity analysis of baicalin nanodrugs: Nanosizing enhances antiviral and anti-inflammatory effects in the treatment of viral pneumonia.

Journal of pharmaceutical analysis·2025
Same author

Mitochondrial Calcium Uniporter Links Acetyl-CoA Metabolism and H3K27 Acetylation to Maintain Glioblastoma Stem Cells.

Cancer research·2025
Same author

Multiple ctDNA- based biomarkers predict benefit from selective RET Inhibition in non-small cell lung cancer patients: exploratory analysis of a prospective study.

Biomarker research·2025
Same author

Cascade Energy Transformation in Hybrid Nanosensitizer Enables Ultrasound-Activated Luminescence Imaging and Enhanced Sonodynamic Therapy.

Journal of the American Chemical Society·2025
Same author

Effectiveness of virtual, group cough modulation therapy for chronic refractory cough.

ERJ open research·2025
Same author

Synthesis of PPy-BiVO<sub>4</sub>-Cu<sup>2+</sup> heterojunction and its visible-light-driven photocatalytic degradation of 2,4-dichlorophenol.

Environmental research·2025

Related Experiment Video

Updated: Aug 15, 2025

Transmission of Multiple Signals through an Optical Fiber Using Wavefront Shaping
09:43

Transmission of Multiple Signals through an Optical Fiber Using Wavefront Shaping

Published on: March 20, 2017

10.0K

Space-variant Shack-Hartmann wavefront sensing based on affine transformation estimation.

Fan Feng, Chen Liang, Dongdong Chen

    Applied Optics
    |January 6, 2023
    PubMed
    Summary

    This study introduces a new method for Shack-Hartmann wavefront sensing to improve deep tissue imaging. The novel approach enhances space-variant wavefront reconstruction accuracy significantly compared to traditional methods.

    More Related Videos

    Compact Lens-less Digital Holographic Microscope for MEMS Inspection and Characterization
    10:28

    Compact Lens-less Digital Holographic Microscope for MEMS Inspection and Characterization

    Published on: July 5, 2016

    10.4K
    Lens-free Video Microscopy for the Dynamic and Quantitative Analysis of Adherent Cell Culture
    09:04

    Lens-free Video Microscopy for the Dynamic and Quantitative Analysis of Adherent Cell Culture

    Published on: February 23, 2018

    9.5K

    Related Experiment Videos

    Last Updated: Aug 15, 2025

    Transmission of Multiple Signals through an Optical Fiber Using Wavefront Shaping
    09:43

    Transmission of Multiple Signals through an Optical Fiber Using Wavefront Shaping

    Published on: March 20, 2017

    10.0K
    Compact Lens-less Digital Holographic Microscope for MEMS Inspection and Characterization
    10:28

    Compact Lens-less Digital Holographic Microscope for MEMS Inspection and Characterization

    Published on: July 5, 2016

    10.4K
    Lens-free Video Microscopy for the Dynamic and Quantitative Analysis of Adherent Cell Culture
    09:04

    Lens-free Video Microscopy for the Dynamic and Quantitative Analysis of Adherent Cell Culture

    Published on: February 23, 2018

    9.5K

    Area of Science:

    • Optics
    • Biomedical Imaging
    • Wavefront Sensing

    Background:

    • Deep tissue imaging faces challenges due to space-variant wavefront distortions.
    • Accurate wavefront reconstruction is crucial for high-resolution imaging in scattering media.

    Purpose of the Study:

    • To propose a novel framework for Shack-Hartmann wavefront sensing that addresses space-variant aberrations.
    • To enhance the accuracy of wavefront reconstruction in deep tissue imaging applications.

    Main Methods:

    • Developed a framework utilizing extended source illumination for Shack-Hartmann sensing.
    • Modeled space-variant wavefronts as four-dimensional functions using affine transformations.
    • Adapted zonal and modal reconstruction methods for the four-dimensional representation.

    Main Results:

    • Demonstrated significant improvements in space-variant wavefront reconstruction accuracy.
    • Achieved double to quadruple accuracy gains compared to conventional space-invariant methods.
    • Validated the framework through both experimental and simulation studies.

    Conclusions:

    • The proposed Shack-Hartmann wavefront sensing framework effectively reconstructs space-variant wavefronts.
    • This method offers a substantial advancement for deep tissue imaging by improving wavefront correction.
    • The findings pave the way for clearer and more detailed imaging within biological tissues.