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Updated: Aug 15, 2025

Methods to Identify the NMR Resonances of the 13C-Dimethyl N-terminal Amine on Reductively Methylated Proteins
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Metal-Free Electrochemically Reductive Deuteration of C═N Bonds with D2O toward Deuterated Amines
Yang Fan1, Wei Ou1, Mengyin Chen2
1International Collaborative Laboratory of 2D Materials for Optoelectronics Science and Technology of Ministry of Education, Institute of Microscale Optoelectronics, Shenzhen University, Shenzhen 518060, P. R. China.
Abstract:
Environmentally friendly and highly efficient synthesis of α-deuterated amines is achieved via a concise electrochemical process using D2O as deuterium source without any external reductants or catalysts. Various imines are compatible, affording the desired products in high yields and D-incorporation. Gram-scale synthesis and flow-cell electrochemistry technology are used to synthesize deuterated pharmaceutical amines and their intermediates. Mechanistic studies reveal a plausible process, including the formation of carbanion species followed by deuterium atom transfer.
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