Association of Islet Amyloid Polypeptide to C-Peptide Ratio With Cystic Fibrosis-Related Diabetes: A Prospective...

Area of Science:

• Endocrinology
• Metabolic Disorders
• Pulmonology

Background:

• Early detection of cystic fibrosis (CF) related diabetes (CFRD) is crucial for improving patient outcomes and reducing mortality.
• Identifying reliable biomarkers for CFRD is essential for timely diagnosis and management.

Purpose of the Study:

• To evaluate the diagnostic potential of the islet amyloid polypeptide (IAPP) to C-peptide ratio in distinguishing between CF patients with and without CFRD.
• To investigate the association of the IAPP:C-peptide ratio with key clinical parameters in CF patients.

Main Methods:

• A cross-sectional analysis was performed on a prospective cohort of 33 participants, including individuals with CF and CFRD.
• Plasma IAPP:C-peptide ratios were measured and correlated with glycated hemoglobin and lung function markers.

Main Results:

• The median IAPP:C-peptide ratio was significantly higher in patients with CFRD compared to those without (P = 0.004).
• The IAPP:C-peptide ratio explained 38% of the variation in diabetes status among CF patients (r2 = 0.399, P < 0.001).
• IAPP levels showed a strong correlation with serum ferritin and forced expiratory volume in CFRD patients.

Conclusions:

• The IAPP:C-peptide ratio shows promise as a potential biomarker for CFRD in adults with CF.
• Further validation in longitudinal studies is necessary to confirm the predictive capability of the IAPP:C-peptide ratio for CFRD.