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Updated: Aug 15, 2025
Simultaneous EEG Monitoring During Transcranial Direct Current Stimulation
Published on: June 17, 2013
Transcranial random noise stimulation over the left dorsolateral prefrontal cortex attenuates pain expectation and
Xiaoyun Li1, Junjie Yao1, Xinxin Lin1
1School of Psychology, Shenzhen University, Shenzhen, Guangdong, China.
Objective:
The dorsolateral prefrontal cortex (DLPFC) has been increasingly used as a neuromodulatory target in pain management. Transcranial random noise stimulation (tRNS) was shown to effectively elevate cortical excitability. Hence, this study aimed to characterize how tRNS over the left DLPFC affects pain expectation and perception, as well as the efficacy of conditioned-pain modulation (CPM) that reflects the function of the endogenous pain-inhibitory pathway.
Methods:
Using a randomized, double-blinded, and sham-controlled design, healthy participants were randomly recruited to receive tRNS with a direct current offset or sham stimulation. Their expectations and perceptions of painful electrocutaneous stimuli, as well as CPM efficacy were assessed before, immediately after, and 30 min after tRNS.
Results:
Compared with sham stimulation, perceived-pain ratings to the painful stimuli, and expected-pain ratings before painful stimuli, attenuated immediately after tRNS, whereas this analgesic effect was ineffective 30 min after tRNS. Importantly, the immediate analgesia induced by tRNS could be accounted for by tRNS effect on attenuating expected-pain ratings before certain painful stimuli. However, CPM efficacy was not significantly affected by tRNS.
Conclusions:
These results demonstrate analgesia immediately after applying tRNS over the left DLPFC.
Significance:
This study provides evidence for analgesia of DLPFC-tRNS on an experimental pain model.
