Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

[Metabolic changes in ischemic brain infarct].

K Schnecker1, W D Rausch, J Bruck

  • 1Ludwig Boltzmann-Institut für Klinische Neurobiologie, Krankenhaus Wien-Lainz.

Wiener Klinische Wochenschrift
|August 28, 1987
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

[Medial end clavicle fractures: alternative osteosynthesis and brief review of the literature].

Unfallchirurgie (Heidelberg, Germany)·2021
Same author

Fumaderm® in daily practice for psoriasis: dosing, efficacy and quality of life.

The British journal of dermatology·2014
Same author

Development of a plasma- and albumin-free recombinant von Willebrand factor.

Hamostaseologie·2009
Same author

The Alpha Project: a model system for systems biology research.

IET systems biology·2008
Same author

Regulatory modules that generate biphasic signal response in biological systems.

Systems biology·2006
Same author

Priming of T cells with Ad-transduced DC followed by expansion with peptide-pulsed DC significantly enhances the induction of tumor-specific CD8+ T cells: implications for an efficient vaccination strategy.

Gene therapy·2003
Same journal

[Vaccination of immunocompromised individuals: Expert opinion - update 2026].

Wiener klinische Wochenschrift·2026
Same journal

Systematic review of clinical evidence for Kneipp medicine.

Wiener klinische Wochenschrift·2026
Same journal

Pelvic resections in primary sarcomas : Surgical outcomes and survival analysis of 75 patients.

Wiener klinische Wochenschrift·2026
Same journal

Jungmediziner*innen am Start: 11. Workshop für den medizinischen Nachwuchs.

Wiener klinische Wochenschrift·2026
Same journal

Stellungnahme der ÖGP zur geplanten Gesetzesnovelle zum Nichtraucherschutzgesetz.

Wiener klinische Wochenschrift·2026
Same journal

MUW researcher of the month: Dr. Moritz Schaefer.

Wiener klinische Wochenschrift·2026
See all related articles

Brain infarction alters serum and cerebrospinal fluid (CSF) metabolite levels. Changes in organic acids and amino acids suggest blood-brain barrier normalization during recovery from stroke.

Area of Science:

  • Neurochemistry
  • Metabolomics
  • Neurology

Context:

  • Brain infarction, or stroke, is a critical neurological event.
  • Assessing metabolic changes in serum and cerebrospinal fluid (CSF) is crucial for understanding stroke pathophysiology.
  • Monitoring these changes during recovery offers insights into healing processes.

Purpose:

  • To analyze organic acids and amino acids in serum and CSF of patients post-brain infarction.
  • To investigate metabolic alterations at acute and recovery stages after stroke.
  • To evaluate the relationship between serum and CSF metabolite concentrations and blood-brain barrier function.

Summary:

  • Serum and CSF were analyzed in 17 patients at acute ( <3 days) and recovery (7 ± 2 days) stages post-brain infarction.

Related Experiment Videos

  • Elevated serum pyruvate was noted at both stages. Acute infarction showed correlated serum-CSF levels for pyruvate and alpha-oxo-beta-methyl valeric acid, which normalized during recovery.
  • Significant changes in L-system and basic transport system amino acids were observed, with some serum-CSF concentration dependencies lost during recovery, indicating potential blood-brain barrier normalization.

    • Impact:

    • Findings suggest specific metabolic profiles associated with acute stroke and recovery.
    • The study provides evidence for blood-brain barrier functional changes post-infarction.
    • Metabolic analysis may offer novel biomarkers for stroke assessment and monitoring.