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Get what you want: Identifying antibodies against pre-defined epitopes on Frizzled receptors
1Faculty of Pharmaceutical Sciences, Ghent University, Ghent, 9000, Belgium.
Structure (London, England : 1993)
|January 7, 2023
Abstract:
In this issue of Structure, Ge et al. report an epitope-directed strategy to select antibodies specific for Frizzled subtypes. Structural and biochemical analyses provide mechanistic insights into the target binding of the isolated antibodies that could guide the design of reagents and therapeutics targeting distinct Frizzled receptors.
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