Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Combined Effects of Drugs: Synergism01:27

Combined Effects of Drugs: Synergism

4.4K
Synergism is a useful mechanism where combining two or more drugs is more effective than each constituent used alone. Such combinations are also called supra-additive interactions. The drugs collectively enhance the final therapeutic effect by acting on different targets. Another advantage is that the low dose of each constituent drug is sufficient to achieve the desired effect. This helps reduce the duration of therapy and lower the adverse effects of these drugs.
Such synergistic combinations...
4.4K
Drugs that Destabilize Microtubules01:10

Drugs that Destabilize Microtubules

2.0K
Microtubules are dynamic structures and can be regulated by microtubule targeting agents (MTAs). Microtubule destabilizing drugs are a class of MTAs that destabilize and prevent microtubules' polymerization. Both natural and synthetic chemicals can be found under this class of drugs. Vincristine and vinblastine, two vinca alkaloids, and colchicine were among the first to be discovered. These drugs can affect cells in various ways, either by inducing a change in cell morphology, preventing...
2.0K
Chemotherapy-Induced Nausea and Vomiting: 5-HT3 Receptor Antagonists01:27

Chemotherapy-Induced Nausea and Vomiting: 5-HT3 Receptor Antagonists

293
5-HT3 receptor antagonists, such as dolasetron, granisetron (Kytril), ondansetron (Zofran), and palonosetron (Axoli), are crucial in managing chemotherapy-induced nausea and vomiting (CINV) and postoperative nausea. These drugs selectively block 5-HT3 receptors in the visceral vagal and spinal afferent nerves, chemoreceptor trigger zone, and the vomiting center. They have a rapid onset of action and can be given as a single dose before chemotherapy. Ondansetron and granisetron, in particular,...
293
Combination Therapies and Personalized Medicine02:50

Combination Therapies and Personalized Medicine

5.0K
Combining two or more treatment methods increases the life span of cancer patients while reducing damage to vital organs or tissue from the overuse of a single treatment. Combination therapy also targets different cancer-inducing pathways, thus reducing the chances of developing resistance to treatment.
The combination of the drug acetazolamide and sulforaphane is a good example of combination therapy to treat cancer. The cells in the interior of a large tumor often die due to the hypoxic and...
5.0K
Drugs that Stabilize Microtubules01:15

Drugs that Stabilize Microtubules

2.1K
Microtubules are dynamic structures that undergo cycles of catastrophe and rescue. The microtubules play a central role in cell division by forming the spindle apparatus for segregating the chromosomes. This makes them ideal targets for regulating dividing cells in tumors and malignant cancer cells. Microtubule stabilizing drugs help stabilize the microtubule formation and promote its polymerization. Paclitaxel was the first microtubule stabilizing agent used as anticancer drug in chemotherapy...
2.1K
Targeted Cancer Therapies02:57

Targeted Cancer Therapies

7.8K
The targeted cancer therapies, also known as “molecular targeted therapies,” take advantage of the molecular and genetic differences between the cancer cells and the normal cells. It needs a thorough understanding of the cancer cells to develop drugs that can target specific molecular aspects that drive the growth, progression, and spread of cancer cells without affecting the growth and survival of other normal cells in the body.
There are several types of targeted therapies against...
7.8K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Discovery of 17-imidazo[1,2-a]pyridinyl-3α-hydroxy-5α-androstanes (17IPAs) as novel potent positive allosteric modulators of the GABA<sub>A</sub> receptor: Synthesis, in vitro and in silico studies.

The Journal of steroid biochemistry and molecular biology·2026
Same author

Borate-Bridged Protolipids: A Prebiotic Route to Abiotic Membranes.

Life (Basel, Switzerland)·2026
Same author

Denitrogenative N-O Coupling of Benzyl Azides with <i>N</i>-Hydroxyphthalimide Mediated by Cerium(IV) Ammonium Nitrate as an Oxidant.

The Journal of organic chemistry·2026
Same author

Boron's Double Edge-Antibiotics, Toxins, and the Fine Line Between Them.

Molecules (Basel, Switzerland)·2026
Same author

Life with Boron: Steroid Architecture and the Chemistry of Marine Boronosteroids.

Marine drugs·2026
Same author

Elemental Sulfur/Base/Water: An Efficient System for the Synthesis of 2-Phosphoryl-Substituted Benzazoles via a Willgerodt-Kindler-Type Reaction.

The Journal of organic chemistry·2026

Related Experiment Video

Updated: Aug 15, 2025

Facile Preparation of 4-Substituted Quinazoline Derivatives
11:51

Facile Preparation of 4-Substituted Quinazoline Derivatives

Published on: February 15, 2016

12.0K

Secosteroid-quinoline hybrids as new anticancer agents.

Alexey I Ilovaisky1, Alexander M Scherbakov2, Valentina M Merkulova1

  • 1N. D. Zelinsky Institute of Organic Chemistry, Russian Academy of Sciences, Leninsky prospect 47, Moscow 119991, Russia.

The Journal of Steroid Biochemistry and Molecular Biology
|January 7, 2023
PubMed
Summary
This summary is machine-generated.

Novel secosteroid-quinoline hybrids show potent anticancer activity against breast cancer cells. The lead compound is significantly more effective than cisplatin and tamoxifen, demonstrating high selectivity and efficacy against drug-resistant cells.

Keywords:
AzomethinesBreast cancerCytotoxicityEstrogen receptor αHydrazidesQuinolinesSecosteroids

More Related Videos

Functionalized Spirocyclic Heterocycle Synthesis and Cytotoxicity Assay
05:17

Functionalized Spirocyclic Heterocycle Synthesis and Cytotoxicity Assay

Published on: February 9, 2021

1.6K
Author Spotlight: Advancing Antimicrobial Resistance Research with Innovative Approaches and Synthetic Compounds
05:59

Author Spotlight: Advancing Antimicrobial Resistance Research with Innovative Approaches and Synthetic Compounds

Published on: September 27, 2024

2.2K

Related Experiment Videos

Last Updated: Aug 15, 2025

Facile Preparation of 4-Substituted Quinazoline Derivatives
11:51

Facile Preparation of 4-Substituted Quinazoline Derivatives

Published on: February 15, 2016

12.0K
Functionalized Spirocyclic Heterocycle Synthesis and Cytotoxicity Assay
05:17

Functionalized Spirocyclic Heterocycle Synthesis and Cytotoxicity Assay

Published on: February 9, 2021

1.6K
Author Spotlight: Advancing Antimicrobial Resistance Research with Innovative Approaches and Synthetic Compounds
05:59

Author Spotlight: Advancing Antimicrobial Resistance Research with Innovative Approaches and Synthetic Compounds

Published on: September 27, 2024

2.2K

Area of Science:

  • Medicinal Chemistry
  • Organic Synthesis
  • Pharmacology

Background:

  • Development of novel anticancer agents is crucial for overcoming drug resistance.
  • Estrogen receptor-positive breast cancer remains a significant health challenge.
  • Secosteroids and quinoline derivatives are scaffolds with known biological activities.

Purpose of the Study:

  • To synthesize novel secosteroid-quinoline hybrids.
  • To evaluate the antiproliferative and antiestrogenic activities of these compounds.
  • To identify potent and selective anticancer agents against breast cancer.

Main Methods:

  • Synthesis of 13,17-secoestra-1,3,5(10)-trien-17-oic acid [N'-(iso)quinolylmethylene]hydrazides.
  • Antiproliferative assays using estrogen-responsive human breast cancer cell line MCF-7.
  • Cytotoxicity evaluation against cisplatin and antiestrogenic activity assessment using luciferase reporter assays compared to tamoxifen.
  • Testing against multidrug-resistant NCI/ADR-RES cells.

Main Results:

  • Most synthesized secosteroid-quinoline hybrids demonstrated superior cytotoxic effects compared to cisplatin.
  • The lead compound exhibited an IC50 value of approximately 0.8 μM, showing 7-fold higher activity than cisplatin.
  • Compounds 2a and 2c displayed high antiestrogenic potency, exceeding that of tamoxifen.
  • These active compounds maintained efficacy against multidrug-resistant NCI/ADR-RES cells.

Conclusions:

  • The novel secosteroid-quinoline hybrids represent a promising class of anticancer agents.
  • The lead compounds possess significant antiproliferative and antiestrogenic activities with high selectivity.
  • These findings warrant further investigation for potential therapeutic applications in breast cancer treatment, including resistant forms.