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Related Experiment Video

Updated: Aug 15, 2025

Determining Basal Energy Expenditure and the Capacity of Thermogenic Adipocytes to Expend Energy in Obese Mice

Determining Basal Energy Expenditure and the Capacity of Thermogenic Adipocytes to Expend Energy in Obese Mice

Published on: November 11, 2021

MR-oximetry with fat DESPOT.

Véronique Fortier¹, Ives R Levesque²

¹Medical Physics Unit, McGill University, Montréal, QC, Canada; Biomedical Engineering, McGill University, Montréal, QC, Canada; Medical Imaging, McGill University Health Centre, Montréal, QC, Canada; Department of Diagnostic Radiology, McGill University, Montréal, QC, Canada; Gerald Bronfman Department of Oncology, McGill University, Montréal, QC, Canada.

Magnetic Resonance Imaging

|January 7, 2023

Summary

This summary is machine-generated.

This study introduces a novel 3D fat R1 mapping technique for MR-oximetry, offering improved spatial coverage and scan times. The new method demonstrates fat R1

Keywords:

Endogenous contrast methods MR-based oximetry Relaxometry Water fat imaging

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Area of Science:

Magnetic Resonance Imaging (MRI)
Biophysics
Medical Physics

Background:

Fat R1 relaxation rate is a crucial biomarker for assessing tissue oxygenation.
Current MR-oximetry techniques for fat R1 mapping face limitations in spatial resolution, scan duration, and clinical scanner compatibility.
Addressing these limitations is essential for advancing non-invasive oxygen monitoring in vivo.

Purpose of the Study:

To develop and validate a 3D voxel-wise fat R1 mapping technique for MR-oximetry.
To overcome the constraints of existing methods, enabling faster and more comprehensive fat R1 measurements.
To utilize a variable flip angle (VFA) approach at 3 Tesla (3T) for improved MR-oximetry.

Main Methods:

A phantom study using safflower oil emulsion to simulate human fat with controlled oxygen levels (pO2).
Implementation of a two-compartment VFA model (Fat DESPOT) for joint voxel-wise fat and water R1 mapping.
Acquisition of multi-echo gradient-echo magnitude data at four flip angles, with inversion-prepared stimulated echo MRI as the reference.

Main Results:

Fat R1 mapping using Fat DESPOT showed higher sensitivity to oxygen variations compared to water R1 and global R1.
The oxygen sensitivity of fat R1 with Fat DESPOT (median r1,O = 1.57×10^-3 s^-1 mmHg^-1) was comparable to spectroscopy-based measurements.
Fat R1 measurements demonstrated a strong correlation with partial pressure of oxygen (pO2) variations.

Conclusions:

The developed Fat DESPOT technique allows for voxel-wise measurement of fat and water R1 within clinically feasible scan times.
Fat and water R1 are sensitive to changes in pO2, validating the potential of this method for MR-oximetry.
This approach offers a promising pathway for 3D in vivo MR oximetry, enhancing tissue oxygenation assessment.