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An update on vaccination in preterm infants

Lilian Dos Santos Rodrigues Sadeck1, Renato de Ávila Kfouri2

  • 1Faculdade de Medicina da Universidade de São Paulo (FMUSP), São Paulo, SP, Brazil; Centro Neonatal do Instituto da Criança e Adolescente do Hospital das Clínicas da Faculdade de Medicina da Universidade de São Paulo (FMUSP), São Paulo, SP, Brazil; Departamento Científico de Neonatologia, Sociedade Brasileira de Pediatria (SBP), São Paulo, SP, Brazil.

Jornal De Pediatria
|January 7, 2023
PubMed

Insights

Vaccines are safe and effective for preterm infants, eliciting protective immune responses. However, delays in infant immunization schedules are common, necessitating universal guidelines to protect this vulnerable population.

Area of Science:

  • Neonatal immunology
  • Vaccinology
  • Pediatric infectious diseases

Background:

  • Preterm infants possess immunological immaturity, posing unique challenges for vaccination.
  • Despite recommendations, preterm infant immunization schedules often face unjustified delays.
  • Vaccination is crucial for preventing diseases in vulnerable preterm infants.

Purpose of the Study:

  • To review current literature on vaccine safety, immunogenicity, and efficacy in preterm newborns.
  • To identify factors contributing to delayed vaccination in preterm infants.
  • To advocate for improved vaccine coverage in this high-risk population.

Main Methods:

  • Comprehensive literature search of recent scientific publications.
  • Focus on studies addressing immunization of preterm infants.
  • Analysis of data on vaccine safety, immunogenicity, and efficacy.

Main Results:

  • Vaccination is generally well-tolerated in preterm infants.
  • Preterm infants demonstrate protective immune responses to vaccines.
  • Significant delays in vaccination schedules for preterm infants are frequently observed.

Conclusions:

  • Routine immunization of preterm infants is essential but often delayed.
  • Developing universal guidelines for preterm infant immunization is critical.
  • Addressing vaccination delays will reduce preventable disease risks in preterm infants.
Abstract

Keywords:
ImmunizationNewbornsPretermVaccination

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