Related Experiment Video

Updated: Aug 15, 2025

Interventional Diagnostic Procedure: A Practical Guide for the Assessment of Coronary Vascular Function
10:28

Interventional Diagnostic Procedure: A Practical Guide for the Assessment of Coronary Vascular Function

Published on: March 15, 2022

5.2K

Clinical Impact of Drug-Coated Balloon-Based Percutaneous Coronary Intervention in Patients With Multivessel Coronary

Eun-Seok Shin1, Eun Jung Jun1, Sunwon Kim2

  • 1Department of Cardiology, Ulsan University Hospital, University of Ulsan College of Medicine, Ulsan, South Korea.

JACC. Cardiovascular Interventions
|January 7, 2023
PubMed

Insights

Drug-coated balloon (DCB) treatment for multivessel coronary artery disease (CAD) significantly reduced stent burden and major adverse cardiovascular events (MACE) compared to drug-eluting stents (DES). This approach offers a safer alternative with improved long-term outcomes.

Area of Science:

  • Interventional Cardiology
  • Vascular Medicine
  • Biomaterials in Medicine

Background:

  • Limited data exist on drug-coated balloon (DCB) efficacy in multivessel coronary artery disease (CAD).
  • Percutaneous coronary intervention (PCI) for multivessel CAD often involves significant stent implantation.

Purpose of the Study:

  • To evaluate the impact of DCB-based treatment on PCI outcomes in patients with multivessel CAD.
  • To compare DCB-based strategies with traditional drug-eluting stent (DES)-only approaches.

Main Methods:

  • Retrospective analysis of 254 patients treated with DCBs (alone or with DES) versus 254 propensity-matched patients treated with second-generation DES.
  • Primary endpoint: Major Adverse Cardiovascular Events (MACE) at 2-year follow-up, including cardiac death, myocardial infarction, stroke, stent thrombosis, target vessel revascularization, and major bleeding.

Main Results:

  • DCB-based treatment significantly reduced stent number (65.4%) and length (63.7%) compared to DES-only.
  • The DCB-based group exhibited a lower MACE rate (3.9% vs. 11.0%; P=0.002) at 2 years.
  • The DES-only group showed a higher incidence of cardiac death and major bleeding.

Conclusions:

  • DCB-based treatment effectively reduces stent burden in multivessel PCI.
  • This approach demonstrates improved long-term outcomes and safety compared to DES-only treatment for multivessel CAD.
  • Reduced stent-related events may contribute to better long-term results with DCB therapy.
Abstract

Keywords:
coronary artery diseasedrug-coated balloondrug-eluting stent(s)multivesselpaclitaxel-coated balloonpercutaneous coronary intervention

More Related Videos

Fully Endoscopic Mitral Valve Repair with Percutaneous Cannulation of Groin Vessels08:12

Fully Endoscopic Mitral Valve Repair with Percutaneous Cannulation of Groin Vessels

Published on: May 26, 2023

1.7K
Utilizing Percutaneous Ventricular Assist Devices in Acute Myocardial Infarction Complicated by Cardiogenic Shock06:10

Utilizing Percutaneous Ventricular Assist Devices in Acute Myocardial Infarction Complicated by Cardiogenic Shock

Published on: June 12, 2021

3.3K

Related Concept Videos

Coronary Artery Disease V: Interprofessional Care01:27

Coronary Artery Disease V: Interprofessional Care

Interprofessional care for coronary artery disease includes pharmacological therapy and revascularization procedures.Pharmacological therapy for Coronary Artery Disease (CAD) aims to manage symptoms, prevent complications, and improve patient outcomes through various classes of medications:Antiplatelet Agents:Aspirin and Clopidogrel: These medications inhibit platelet aggregation, preventing blood clots, which is crucial for avoiding heart attacks and strokes. Doctors often prescribe these...
22
Peripheral Artery Disease III: Interprofessional Care01:27

Peripheral Artery Disease III: Interprofessional Care

Peripheral Artery Disease (PAD) is characterized by narrowed arteries that diminish blood flow to the extremities. Effective management of PAD requires an interprofessional approach involving various healthcare professionals. The critical aspects of interprofessional care for PAD patients focus on risk factor modification, drug therapy, exercise therapy, nutrition therapy, critical limb ischemia care, and interventional radiology and surgical procedures.The primary treatment goal for PAD...
18
Coronary Artery Disease IV: Preventive Measures01:26

Coronary Artery Disease IV: Preventive Measures

Effective preventive measures for coronary artery disease (CAD) focus on controlling modifiable risk factors, including cholesterol abnormalities and lifestyle changes.Cholesterol ManagementFirst, the Mediterranean diet and the American Heart Association advocate for maintaining low-density lipoprotein (LDL) cholesterol levels below 100 mg/dL, with a more stringent recommendation of below 70 mg/dL for individuals at high risk. LDL cholesterol, often termed "bad cholesterol," can lead to the...
31
Antianginal Drugs: Calcium Channel Blockers and Ranolazine01:25

Antianginal Drugs: Calcium Channel Blockers and Ranolazine

Angina pectoris, a primary symptom of ischemic heart disease, requires careful pharmacological interventions. In this context, calcium channel blockers (CCBs) and ranolazine have emerged as crucial pharmacotherapeutic agents, providing deep insights into the complexities of angina management.
CCBs, a diverse class that includes dihydropyridines (nifedipine) and diphenylalkylamines (verapamil and diltiazem), exert their effect by blocking calcium channels in cardiac and smooth muscle cells. This...
613
Acute Coronary Syndrome IV: Interprofessional Care01:28

Acute Coronary Syndrome IV: Interprofessional Care

IntroductionThe management of Acute Coronary Syndrome (ACS) aims to minimize myocardial damage, preserve myocardial function, and prevent complications.Initial ManagementInpatient management involves continuous cardiac monitoring, preferably in an ICU, focusing on blood pressure, serum sodium, potassium, and creatinine levels, and urine output. Ongoing pharmacologic management is crucial for stabilizing the patient.Supplemental Oxygen: Administer supplemental oxygen if oxygen saturation is...
20
Angina IV: Management01:26

Angina IV: Management

IntroductionThe management of angina requires a comprehensive approach that includes pharmacological therapies, medical procedures, and lifestyle modifications.Pharmacological TherapiesAntiplatelet agents, such as aspirin, clopidogrel, prasugrel, and ticagrelor, play a pivotal role in preventing thrombus formation in patients with angina. These medications inhibit platelet aggregation and reduce the likelihood of myocardial infarction and other cardiovascular events.Anticoagulants, including...
14