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Related Experiment Video

Updated: Aug 15, 2025

Psychophysical Tracking Method to Measure Taste Preferences in Children and Adults
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Sweet Taste Receptor Gene and Caries Trajectory in the Life Course.

L A Chisini1, F D S Costa2, B L Horta3

  • 1Graduate Program in Dentistry, Federal University of Juiz de Fora, Governador Valadares, MG, Brazil.

Journal of Dental Research
|January 7, 2023
PubMed
Summary

Genetic variants in TAS1R3 (rs307355) are linked to life-course dental caries trajectories, specifically the decayed and missing teeth components. An epistatic interaction between TAS1R3 and TAS1R2 (rs35874116) may further elevate the risk of decayed teeth.

Keywords:
DMF-TTAS1R2TAS1R3dental carieslongitudinal studysingle-nucleotide polymorphism

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Area of Science:

  • Genetics
  • Dental Epidemiology
  • Life Course Studies

Background:

  • Dental caries is a multifactorial disease influenced by genetic and environmental factors.
  • Understanding genetic predispositions across the life course is crucial for targeted prevention strategies.

Purpose of the Study:

  • To investigate the association between TAS1R3 (rs307355) and TAS1R2 (rs35874116) gene variants and dental caries trajectories.
  • To explore potential epistatic interactions between these variants in a life-course perspective.

Main Methods:

  • Prospective investigation of the 1982 Pelotas birth cohort (n=5,914).
  • Assessment of decayed, missing, and filled teeth (DMF-T) components at ages 15, 24, and 31.
  • Group-based trajectory modeling and genetic genotyping (rs307355, rs35874116) with ADMIXTURE and generalized multifactor dimensionality reduction for epistasis analysis.

Main Results:

  • The TT genotype of rs307355 (TAS1R3) was associated with high decayed (OR=4.52) and missing (OR=3.35) trajectory groups.
  • Allele T of rs307355 was linked to increased odds of decayed (OR=1.64) and missing (OR=1.41) components.
  • rs35874116 (TAS1R2) showed no significant association with DMF-T components.
  • Positive epistatic interactions between rs307355 and rs35874116 were observed for the decayed component (OR=1.72).

Conclusions:

  • rs307355 (TAS1R3) genotypes and alleles are associated with life-course trajectories of decayed and missing dental caries components.
  • Epistatic interaction between rs307355 and rs35874116 may contribute to increased decayed caries trajectories.
  • These findings highlight the role of specific genetic variants in the long-term development of dental caries.