Optimization of ethanol-modified subcritical water extraction of curcuminoids from turmeric (Curcuma longa L.)...

Subcritical solvent extraction (SSE) as ethanol-modified subcritical water extraction (SWE) was applied to extract curcuminoids from turmeric (Curcuma longa L.) rhizomes. RSM-CCD was employed to evaluate the influential factors including temperature (90-150 °C), flow rate (1-4 mL/min), and ethanol concentration (25-75 wt%) on the extraction yield. The optimum condition was 90 °C, 4 mL/min, and 25 wt% with the extraction yield of 4.12 wt% (db). Applying ethanol as a polarity-tuning parameter enabled operations at lower temperatures, which prevented thermal degradation. The SSE optimum experiment was compared with Soxhlet, ultrasound-assisted extraction (UAE) and conventional solvent extraction (CSE), both with the ethanol-water mixture (25 wt%). Their yields were 2.71, 0.85, and 0.84 wt% (db), respectively. The higher yield of SSE was related to the higher solubility of curcuminoids due to the more appropriate adjustment of solvent polarity by a decrease in the dielectric constant with a rise in the operating temperature.