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Antioxidative hypoglycemic herbal medicines with in vivo and in vitro activity against C-reactive protein; a
Maryam Mirahmad1, Shahrzad Mohseni1, Ozra Tabatabaei-Malazy2
1Endocrinology and Metabolism Research Center, Endocrinology and Metabolism Clinical Sciences Institute, Tehran University of Medical Sciences, Tehran, Iran.
Background:
Inflammation is a double-edged sword in the pathophysiology of chronic diseases, such as type 2 diabetes mellitus (T2DM). The global rise in the prevalence of T2DM in one hand, and poor disease control with currently-available treatments on the other hand, along with an increased tendency towards the use of natural products make scientists seek herbal medicines for the management of diabetes and its complications by reducing C-reactive protein (CRP) as an inflammatory marker.
Purpose:
To systematically review the literature to identify the efficacy of various medicinal plants with antioxidative and anti-inflammatory properties considering their effect on CRP in animal models of T2DM.
Study Design:
systematic review.
Methods:
Electronic databases including PubMed, Scopus, Web of Science and Cochran Library were searched using the search terms "herbal medicine", "diabetes", "c-reactive protein", "antioxidants" till August 2021. The quality of evidence was assessed using the Systematic Review Centre for Laboratory animal Experimentation (SYRCLE's) tool. The study protocol was registered in PROSPERO with an ID number CRD42020207190. A manual search to detect any articles not found in the databases was also made. The identified studies were then critically reviewed and relevant data were extracted and summarized.
Results:
Among total of 9904 primarily-retrieved articles, twenty-three experimental studies were finally included. Our data indicated that numerous herbal medicines, compared to placebo or hypoglycemic medications, are effective in treatment of diabetes and its complications through decreasing CRP concentrations and oxidative stresses levels. Medicinal plants including Psidium guajava L., Punica granatum L., Ginkgo biloba L., Punica granatum L., Dianthus superbusn L.. Moreover, Eichhornia crassipes (Mart.) Solms, Curcuma longa L., Azadirachta indica A. Juss., Morus alba L., and Ficus racemosa L. demonstrated potential neuroprotective effects in animal models of diabetes.
Conclusion:
Hypoglycemic medicinal plants discussed in this review seem to be promising regulators of CRP, and oxidative stress. Thus, these plants are suitable candidates for management of diabetes' complications. Nevertheless, further high-quality in vivo studies and clinical trials are required to confirm these effects.
Insights
This systematic review found that numerous herbal medicines effectively reduce C-reactive protein (CRP) and oxidative stress in animal models of type 2 diabetes mellitus (T2DM). These natural compounds show promise for managing diabetes complications.
Area of Science:
- Pharmacology
- Natural Product Research
- Endocrinology
Background:
- Inflammation plays a critical role in type 2 diabetes mellitus (T2DM) pathophysiology.
- Current T2DM treatments have limitations, driving interest in natural products.
- C-reactive protein (CRP) is a key inflammatory marker in T2DM management.
Approach:
- Systematic review of literature up to August 2021.
- Searched PubMed, Scopus, Web of Science, and Cochran Library for studies on herbal medicine, diabetes, CRP, and antioxidants.
- Assessed evidence quality using SYRCLE's tool and registered protocol in PROSPERO.
Key Points:
- Twenty-three experimental studies were included from 9904 initial articles.
- Numerous herbal medicines demonstrated efficacy in reducing CRP and oxidative stress in T2DM animal models.
- Specific plants like Psidium guajava, Punica granatum, and Curcuma longa showed significant effects, with some exhibiting neuroprotective properties.
Conclusions:
- Hypoglycemic medicinal plants are promising regulators of CRP and oxidative stress in T2DM.
- These plants offer potential for managing diabetes complications.
- Further high-quality in vivo studies and clinical trials are needed to confirm efficacy.
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