Case Report: Isosulfan Blue-Related Anaphylaxis

Area of Science:

• Anesthesiology
• Allergy and Immunology

Background:

• Anaphylaxis is a critical systemic allergic reaction caused by mast cell and basophil mediator release.
• Isosulfan blue dye is a rare but documented cause of anaphylaxis, occurring in 0.16% to 2% of cases.

Observation:

• This report details two intraoperative cases of anaphylaxis linked to isosulfan blue dye administration.
• Both patients experienced severe (grade 3) anaphylactic reactions.

Findings:

• The reactions manifested as significant hypotension requiring vasopressor treatment.
• Both patients necessitated intensive care unit (ICU) admission for monitoring and management.

Implications:

• These cases highlight isosulfan blue dye as a potential intraoperative anaphylaxis trigger.
• Anesthesiologists and surgeons should be aware of this risk and prepared for prompt management.
• Further research into isosulfan blue dye-induced anaphylaxis may be warranted.