Related Experiment Video

Updated: Aug 15, 2025

Visualization of SARS-CoV-2 using Immuno RNA-Fluorescence In Situ Hybridization
05:23

Visualization of SARS-CoV-2 using Immuno RNA-Fluorescence In Situ Hybridization

Published on: December 23, 2020

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SARS-CoV-2 Infection: What Is Currently Known about Homocysteine Involvement?

Nina Filip1, Elena Cojocaru2, Oana Viola Badulescu3

  • 1Department of Morpho-Functional Sciences (II), Discipline of Biochemistry, Faculty of Medicine, "Grigore T. Popa" University of Medicine and Pharmacy, 700115 Iasi, Romania.

Diagnostics (Basel, Switzerland)
|January 8, 2023
PubMed

Insights

This review examines homocysteine

Area of Science:

  • Biochemistry
  • Infectious Diseases
  • Cardiovascular Medicine

Background:

  • Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has caused global health and economic disruption since December 2019.
  • Comorbidities significantly impact SARS-CoV-2 infection severity and patient prognosis.
  • Thrombosis is a critical complication in COVID-19 patients.

Purpose of the Study:

  • To analyze current data on homocysteine's role in COVID-19.
  • To investigate the correlation between homocysteine levels and COVID-19 disease severity.
  • To explore potential mechanisms of homocysteine's involvement in COVID-19.

Main Methods:

  • Literature review of studies investigating homocysteine and COVID-19.
  • Analysis of data correlating homocysteine levels with clinical outcomes.
  • Synthesis of proposed pathophysiological mechanisms.

Main Results:

  • Elevated homocysteine levels are associated with increased COVID-19 severity.
  • Homocysteine may contribute to thrombosis in COVID-19 patients.
  • Potential mechanisms include endothelial dysfunction and inflammation.

Conclusions:

  • Homocysteine is implicated in the pathophysiology of severe COVID-19.
  • Homocysteine may serve as a biomarker for thrombotic risk in COVID-19.
  • Further research is needed to elucidate homocysteine's precise role and therapeutic implications.

Keywords:
MTHRFSARS-CoV-2cardiovascular diseasehomocysteinethrombosis

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