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Related Experiment Videos

Malignant Brenner tumor with peritoneal metastasis.

K Hayashi1, K Takahashi, H Sonobe

  • 1Second Department of Pathology, Kochi Medical School, Nankoku, Japan.

Acta Pathologica Japonica
|July 1, 1987
PubMed
Summary

This case report details a rare malignant Brenner tumor with peritoneal metastasis in a 67-year-old woman. The study highlights key diagnostic features of this ovarian cancer subtype.

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Area of Science:

  • Gynecologic Oncology
  • Pathology
  • Surgical Oncology

Background:

  • Malignant Brenner tumors are rare epithelial ovarian neoplasms with transitional cell differentiation.
  • Distinguishing malignant Brenner tumors from benign counterparts and other ovarian cancers is crucial for appropriate management.

Observation:

  • A 67-year-old woman presented with a large, multilocular cystic right ovarian tumor (420g) exhibiting papillary patterns.
  • Histological examination revealed transitional cell carcinoma with glandular elements, resembling high-grade urinary bladder carcinoma.
  • Areas of proliferating Brenner tumor were noted, but the benign pattern was absent.

Findings:

  • Immunohistochemistry showed carcinoembryonic antigen in tumor cells and intercellular spaces, and cytokeratin in some cells.

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  • Ultrastructural analysis identified features common to benign Brenner tumors and bladder tumors, including intercellular spaces with microvilli.
  • The tumor demonstrated peritoneal metastasis.

    • Implications:

    • This case underscores the importance of detailed morphological and ultrastructural analysis for diagnosing rare ovarian tumors.
    • The presence of intercellular spaces with microvilli may be a significant diagnostic criterion.
    • Understanding the features of malignant Brenner tumors aids in accurate diagnosis and treatment planning for advanced ovarian cancers.