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Updated: Aug 15, 2025

MicroRNA-based Regulation of Picornavirus Tropism
Published on: February 6, 2017
MicroRNAs in T Cell-Immunotherapy
Sara G Dosil1,2,3, Ana Rodríguez-Galán1,2,3, Francisco Sánchez-Madrid1,2,3,4
1Immunology Service, Hospital Universitario de la Princesa, Instituto Investigación Sanitaria Princesa, 28006 Madrid, Spain.
Abstract:
MicroRNAs (miRNAs) act as master regulators of gene expression in homeostasis and disease. Despite the rapidly growing body of evidence on the theranostic potential of restoring miRNA levels in pre-clinical models, the translation into clinics remains limited. Here, we review the current knowledge of miRNAs as T-cell targeting immunotherapeutic tools, and we offer an overview of the recent advances in miRNA delivery strategies, clinical trials and future perspectives in RNA interference technologies.
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