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In Vitro Bioluminescence Assay to Characterize Circadian Rhythm in Mammary Epithelial Cells
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Circadian Rhythm Disorders Aggravate Periodontitis by Modulating BMAL1
Xiaomeng Liu1, Niuben Cao1, Xinchan Liu2
1Department of Periodontics, School of Dentistry, Jilin University, Changchun 130021, China.
International Journal of Molecular Sciences
|January 8, 2023
Summary
Circadian rhythm disorders (CRD) downregulate BMAL1, a key gene in periodontitis. This exacerbates bone loss, inflammation, and cell damage, offering new treatment perspectives for periodontitis.
Area of Science:
- Chronobiology
- Periodontology
- Molecular Biology
Background:
- Circadian rhythms regulate homeostasis via tissue-specific genes.
- Circadian rhythm disorders (CRD) impact BMAL1, linked to metabolic and immune issues.
- The CRD-periodontitis link and BMAL1's role remain unclear.
Purpose of the Study:
- Investigate BMAL1's role in periodontitis.
- Examine the impact of CRD on BMAL1 expression and periodontitis development.
Main Methods:
- Utilized a modified multi-platform approach (MMPM) to induce CRD in rats.
- Analyzed BMAL1 expression, alveolar bone resorption, osteoclast differentiation, NF-κB signaling, apoptosis, and oxidative stress.
Main Results:
- CRD with periodontitis showed significant BMAL1 downregulation.
- Increased alveolar bone resorption, osteoclast differentiation, and NF-κB upregulation were observed.
- Elevated apoptosis and oxidative stress in periodontal tissues were noted.
Conclusions:
- BMAL1 is a key regulator in CRD-exacerbated periodontitis.
- CRD may downregulate BMAL1, worsening oxidative stress and apoptosis.
- BMAL1's association with periodontitis progression offers novel therapeutic targets.
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