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Relationships between Diabetes and the Intestinal Microbial Population.

Stephen C Bondy1,2

  • 1Department of Medicine, Center for Occupational and Environmental Health, University of California, Irvine, CA 92697, USA.

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|January 8, 2023
PubMed
Summary
This summary is machine-generated.

The gut microbiome influences diabetes development and progression. This review explores the bidirectional relationship between gut bacteria, diet, and metabolic changes, highlighting short-chain fatty acids (SCFAs) as key mediators.

Keywords:
butyratediabetesdietintestinal bacteriamicrobiome

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Area of Science:

  • Microbiology
  • Endocrinology
  • Metabolic Disorders

Background:

  • Diabetes mellitus is a metabolic disorder with significant glucose level fluctuations.
  • Both hyperglycemia and hypoglycemia are detrimental to health.
  • Type 1 diabetes (T1D) has a genetic basis and autoimmune component, while Type 2 diabetes (T2D) is influenced by diet.

Purpose of the Study:

  • To review the relationship between intestinal bacteria and diabetes.
  • To discuss the bidirectional interaction between the gut microbiome and diabetes.
  • To emphasize the role of diet in shaping both the microbiome and diabetes incidence.

Main Methods:

  • Literature review focusing on the gut microbiome and diabetes.
  • Analysis of studies investigating diet-microbiome interactions.
  • Examination of metabolic changes associated with altered microbiomes.

Main Results:

  • Gut microbiome composition is a recognized factor in overall health.
  • The gut microbiome plays a marked role in diabetes.
  • Diet significantly impacts both the microbiome and diabetes incidence.

Conclusions:

  • The gut microbiome is intricately linked to the establishment and maintenance of diabetes.
  • Dietary factors mediate the relationship between the gut microbiome and diabetes.
  • Short-chain fatty acids (SCFAs) are crucial mediators in the microbiome-diabetes axis.