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Microbiota Analysis Using Two-step PCR and Next-generation 16S rRNA Gene Sequencing
Published on: October 15, 2019
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Relationships between Diabetes and the Intestinal Microbial Population
1Department of Medicine, Center for Occupational and Environmental Health, University of California, Irvine, CA 92697, USA.
International Journal of Molecular Sciences
|January 8, 2023
Summary
The gut microbiome influences diabetes development and progression. This review explores the bidirectional relationship between gut bacteria, diet, and metabolic changes, highlighting short-chain fatty acids (SCFAs) as key mediators.
Area of Science:
- Microbiology
- Endocrinology
- Metabolic Disorders
Background:
- Diabetes mellitus is a metabolic disorder with significant glucose level fluctuations.
- Both hyperglycemia and hypoglycemia are detrimental to health.
- Type 1 diabetes (T1D) has a genetic basis and autoimmune component, while Type 2 diabetes (T2D) is influenced by diet.
Purpose of the Study:
- To review the relationship between intestinal bacteria and diabetes.
- To discuss the bidirectional interaction between the gut microbiome and diabetes.
- To emphasize the role of diet in shaping both the microbiome and diabetes incidence.
Main Methods:
- Literature review focusing on the gut microbiome and diabetes.
- Analysis of studies investigating diet-microbiome interactions.
- Examination of metabolic changes associated with altered microbiomes.
Main Results:
- Gut microbiome composition is a recognized factor in overall health.
- The gut microbiome plays a marked role in diabetes.
- Diet significantly impacts both the microbiome and diabetes incidence.
Conclusions:
- The gut microbiome is intricately linked to the establishment and maintenance of diabetes.
- Dietary factors mediate the relationship between the gut microbiome and diabetes.
- Short-chain fatty acids (SCFAs) are crucial mediators in the microbiome-diabetes axis.
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