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Advances in Multifunctional Bioactive Coatings for Metallic Bone Implants.

Maria P Nikolova1, Margarita D Apostolova2

  • 1Department of Material Science and Technology, University of Ruse "A. Kanchev", 8 Studentska Str., 7017 Ruse, Bulgaria.

Materials (Basel, Switzerland)
|January 8, 2023
PubMed
Summary

Metallic bone implants face challenges like low biocompatibility and wear. Bioactive coatings, including ceramics and polymers, enhance implant performance and biocompatibility for better orthopedic applications.

Keywords:
bioactive coatingscoating techniquescombinatorial treatmentscontrolled releasemetallic implantssurface modifications

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Area of Science:

  • Biomaterials Science
  • Orthopedic Surgery
  • Materials Engineering

Background:

  • Metallic implants are crucial in orthopedics for load-bearing applications.
  • Current metallic implants face limitations including poor biocompatibility, wear, corrosion, and infection.
  • Coatings are essential for improving the in vitro and in vivo performance of metallic implants.

Purpose of the Study:

  • To systematically review bioactive and high-performance coatings for metallic bone implants.
  • To discuss the biocompatibility of these advanced coatings.
  • To provide updates on coating materials, formulations, and production routes.

Main Methods:

  • Literature review of bioactive and high-performance coatings for metallic bone implants.
  • Analysis of coating materials, formulations, and production techniques.
  • Discussion on strategies for enhancing coating performance through bioactive moieties.

Main Results:

  • Bio-ceramic and polymer coatings can create composite implants with enhanced bioactive, osteogenic, antibacterial, or biodegradable properties.
  • Various coating materials and production routes have been updated.
  • Incorporating bioactive factors (growth factors, antibiotics, etc.) improves coating performance through controlled local release.

Conclusions:

  • Bioactive coatings significantly enhance the performance and biocompatibility of metallic bone implants.
  • Advanced coating strategies address key limitations of traditional metallic implants.
  • Future developments focus on controlled release of therapeutic agents from coatings for improved patient outcomes.