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Malignant transformation of gastric hyperplastic polyps.
M Daibo1, M Itabashi, T Hirota
1Pathology Division, National Cancer Center Research Institute, Tokyo, Japan.
The American Journal of Gastroenterology
|October 1, 1987
Summary
Malignant transformation in hyperplastic polyps is rare but possible. Cancer cells in these polyps appear to originate from dysplastic areas, not directly from hyperplastic tissue.
Area of Science:
- Gastroenterology
- Pathology
- Oncology
Background:
- Hyperplastic polyps are common gastrointestinal findings.
- The malignant potential of hyperplastic polyps remains a subject of investigation.
Purpose of the Study:
- To investigate the incidence of malignant transformation in hyperplastic polyps.
- To determine the origin of cancer within hyperplastic polyps.
Main Methods:
- Review of 477 hyperplastic polyps removed via endoscopic polypectomy.
- Histopathological examination for dysplastic foci and carcinoma.
- Clinicopathological examination and immunohistochemical staining.
Main Results:
- Focal intramucosal carcinomas were identified in 2.1% (10/477) of hyperplastic polyps.
- Dysplastic foci, similar to adenomas, were adjacent to cancerous foci in these 10 polyps.
- Dysplastic foci without cancer were found in 4.0% (19/477) of hyperplastic polyps.
Conclusions:
- Malignant transformation in hyperplastic polyps is associated with the presence of dysplastic foci.
- Cancer cells in hyperplastic polyps likely arise from these dysplastic areas, not directly from hyperplastic epithelium.