Synthesis, Characterization and Biological Investigations of Half-Sandwich Ruthenium(II) Complexes Containing...

Area of Science:

• Organometallic Chemistry
• Medicinal Chemistry
• Materials Science

Background:

• Half-sandwich ruthenium(II) complexes are known for biological activity.
• Benzimidazole derivatives are common in medicinal chemistry.

Purpose of the Study:

• Synthesize and characterize novel arene ruthenium complexes with benzimidazole moieties.
• Evaluate the antimicrobial, cytotoxic, and lipophilicity properties of these complexes.
• Investigate potential interactions with human serum albumin (HSA).

Main Methods:

• Synthesis of [(η⁶-p-cymene)RuCl(bimCOO)] and [(η⁶-p-cymene)RuCl₂(bim)] complexes.
• Characterization using NMR, IR, UV-vis, CV, and SC-XRD.
• Antimicrobial assays against bacterial strains (S. aureus, E. coli, P. aeruginosa).
• Cytotoxicity testing on human fibroblasts and epithelial cells.
• Molecular docking studies with HSA.

Main Results:

• Novel ruthenium(II) complexes with pseudo-tetrahedral geometry were synthesized and characterized.
• Complexes exhibited bacteriostatic activity against Pseudomonas aeruginosa PAO1.
• No significant toxicity was observed in normal human cell lines.
• Hirshfeld surface analysis provided insights into crystal interactions.

Conclusions:

• The synthesized ruthenium complexes demonstrate selective antimicrobial activity.
• These compounds represent promising candidates for developing new antibacterial agents.
• Further studies on HSA binding can elucidate their transport mechanism.