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Updated: Aug 15, 2025

Isolation of Primary Mouse Hepatocytes for Nascent Protein Synthesis Analysis by Non-radioactive L-azidohomoalanine Labeling Method
Published on: October 23, 2018
Pectin in Metabolic Liver Disease
Wanchao Hu1, Anne-Marie Cassard1,2, Dragos Ciocan1,2,3
1Faculté de Pharmacie, Université Paris-Saclay, Inserm U996, Inflammation, Microbiome and Immunosurveillance, Bâtiment Henri MOISSAN, 17 Avenue des Sciences, 91400 Orsay, France.
Abstract:
Alterations in the composition of the gut microbiota (dysbiosis) are observed in nutritional liver diseases, including non-alcoholic fatty liver disease (NAFLD) and alcoholic liver disease (ALD) and have been shown to be associated with the severity of both. Editing the composition of the microbiota by fecal microbiota transfer or by application of probiotics or prebiotics/fiber in rodent models and human proof-of-concept trials of NAFLD and ALD have demonstrated its possible contribution to reducing the progression of liver damage. In this review, we address the role of a soluble fiber, pectin, in reducing the development of liver injury in NAFLD and ALD through its impact on gut bacteria.
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