Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Reversible acute decrease in renal function by NSAIDs in cirrhosis.

D C Brater1, S A Anderson, D Brown-Cartwright

  • 1University of Texas Health Science Center at Dallas, Department of Pharmacology.

The American Journal of the Medical Sciences
|September 1, 1987
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Vaccine safety surveillance in Kenya using GAIA standards: A feasibility assessment of existing national and subnational research and program systems.

Vaccine·2023
Same author

A risk assessment model for transfusion transmission of dengue.

Letters in applied microbiology·2022
Same author

A modified dose-response model that describes the relationship between haemagglutination inhibition titre and protection against influenza infection.

Journal of applied microbiology·2017
Same author

Stem cell-derived interneuron transplants as a treatment for schizophrenia: preclinical validation in a rodent model.

Molecular psychiatry·2016
Same author

Clotting Factor (Cf) Product Use And Same-Day Risk For Thrombotic Adverse Events (Tes), As Recorded In Large Health Care Database During 2008-2013 Study Period.

Value in health : the journal of the International Society for Pharmacoeconomics and Outcomes Research·2016
Same author

Modeling complete removal of risk assessment questions in the USA predicts the risk of HIV exposure in blood recipients could increase despite the use of nucleic acid testing.

Vox sanguinis·2016
Same journal

Providers' Perspectives on Hospital-Based Tobacco Treatment Efforts.

The American journal of the medical sciences·2026
Same journal

In Memoriam: Maurice A. Mufson, MD, MACP.

The American journal of the medical sciences·2026
Same journal

Outcomes of acute myeloid leukemia patients admitted to the intensive care unit within 100 days of allogeneic hematopoietic stem cell transplantation.

The American journal of the medical sciences·2026
Same journal

Association Between Reverse Triiodothyronine and Cardiac Complications in Patients with Uncontrolled Graves' Disease.

The American journal of the medical sciences·2026
Same journal

Chlorthalidone vs. hydrochlorothiazide in hypertension management: Lessons for guiding clinical practice.

The American journal of the medical sciences·2026
Same journal

The impact of COVID-19 on alcohol-associated hepatitis and alcohol-associated cirrhosis.

The American journal of the medical sciences·2026
See all related articles

Nonsteroidal anti-inflammatory drugs (NSAIDs) like sulindac can impair kidney function in patients with severe alcoholic cirrhosis. These drugs, including ibuprofen and naproxen, reduced renal function and prostanoid levels in study participants.

Area of Science:

  • Nephrology
  • Hepatology
  • Pharmacology

Background:

  • Severe alcoholic cirrhosis significantly impacts renal function.
  • Nonsteroidal anti-inflammatory drugs (NSAIDs) are commonly used but can pose renal risks.

Purpose of the Study:

  • To compare the effects of sulindac, ibuprofen, and naproxen on renal function and prostanoids in patients with severe alcoholic cirrhosis.
  • To assess the safety profile of sulindac in this patient population.

Main Methods:

  • Prospective study comparing sulindac, ibuprofen, and naproxen in patients with severe alcoholic cirrhosis.
  • Monitoring of creatinine clearance and urinary prostanoid levels (PGE2, TxB2, 6-keto PGF1 alpha).

Main Results:

  • Sulindac caused acute declines in renal parameters in 4 out of 5 patients, even at therapeutic metabolite concentrations.

Related Experiment Videos

  • The unaffected patient showed minimal prostanoid changes with sulindac but significant declines with ibuprofen.
  • Ibuprofen and naproxen also led to decrements in renal parameters in other patients.

    • Conclusions:

    • Sulindac suppresses renal prostanoids and reduces creatinine clearance in patients with severe alcoholic cirrhosis.
    • NSAIDs, including sulindac, ibuprofen, and naproxen, require cautious use in cirrhotic patients due to potential nephrotoxicity.