[Senescence-associated secretory phenotype and inflammaging: the role in cardiovascular diseases.]
D V Savitskiy1, N S Linkova1,2, A S Diatlova1
1Saint-Petersburg Institute of Bioregulation and Gerontology, 3 pr. Dynamo, St. Petersburg 197110, Russian Federation.
Abstract:
Senescent cells take part into development the age-related diseases by formation the SASP: senescence-associated secretory phenotype. SASP is characterized by synthesis of signal molecules include proinflammatory cytokines. SASP promotes the inflammaging - chronic, low-grade, subclinical inflammatory process, that is the one of cardio-vascular diseases risk factor in older age-groups. In the review we describe the key SASP molecules of cardiomyocytes, endotheliocytes and vascular smooth muscle cells and its role in the pathogenesis of age-associated cardiovascular diseases.
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