Related Experiment Video

Updated: Aug 15, 2025

3D-Neuronavigation In Vivo Through a Patient's Brain During a Spontaneous Migraine Headache
10:39

3D-Neuronavigation In Vivo Through a Patient's Brain During a Spontaneous Migraine Headache

Published on: June 2, 2014

18.3K

Medication-overuse headache: clinical profile and management strategies

Khalid W AlQuliti1, Rakan M Alhujeily1

  • 1Division of Neurology, Department of Medicine, College of Medicine, Taibah University, Madinah Al-Munawarah, Kingdom of Saudi Arabia.

Neurosciences (Riyadh, Saudi Arabia)
|January 8, 2023
PubMed

Insights

Medication-overuse headache (MOH) is a common cause of chronic headaches, affecting 1-2% of adults. Understanding its mechanisms and new treatments can improve patient outcomes and reduce healthcare costs.

Area of Science:

  • Neurology
  • Headache Medicine
  • Clinical Neuroscience

Background:

  • Medication-overuse headache (MOH) is a prevalent secondary headache disorder impacting 1-2% of the global adult population.
  • It presents significant challenges for patients and healthcare systems due to its disabling nature and high prevalence in productive age groups.
  • Regular overuse of acute headache medications for over three months in patients with primary headache disorders defines MOH.

Purpose of the Study:

  • To review the current understanding of Medication-overuse headache (MOH).
  • To identify updated clinical assessment strategies for MOH.
  • To explore recent management approaches and treatment options for MOH.

Main Methods:

  • Literature review of recent advances in headache neurosciences.
  • Analysis of clinical profiles and pathophysiological mechanisms of MOH.
  • Synthesis of updated diagnostic criteria and therapeutic guidelines.

Main Results:

  • MOH is a complex condition with significant patient and healthcare burdens.
  • Advances in neuroscience offer new insights into MOH pathophysiology.
  • Emerging treatments show promise for improving patient outcomes.

Conclusions:

  • Improved understanding of MOH pathophysiology is crucial for effective management.
  • Updated clinical assessments and novel treatments can alleviate the burden of MOH.
  • Targeted interventions are needed to improve patient outcomes and reduce healthcare resource utilization.

More Related Videos

Author Spotlight: Deciphering Electrical Networks Behind Complex Brain Activities and Disorders05:49

Author Spotlight: Deciphering Electrical Networks Behind Complex Brain Activities and Disorders

Published on: November 1, 2024

880
Author Spotlight: Methodologies and Advancements of Chronic Pain Management Research08:33

Author Spotlight: Methodologies and Advancements of Chronic Pain Management Research

Published on: January 5, 2024

1.3K

Related Concept Videos

Analgesia and Pain Management01:25

Analgesia and Pain Management

Pain is critical to various clinical pathologies, provoking an urgent need for effective management. Pain, whether acute or chronic, is a complex neurochemical process. Its alleviation depends on the type, with nonopioid analgesics effective for mild to moderate pain, such as musculoskeletal or inflammatory pain, while neuropathic pain responds best to anticonvulsants, tricyclic antidepressants, or serotonin/norepinephrine reuptake inhibitors. For severe acute or chronic pain, opioids may be...
711
Management of Insomnia01:19

Management of Insomnia

The sleep cycle, an integral part of human health, consists of several stages with distinct characteristics and functions. It begins with a transition from wakefulness to sleep, known as the light sleep phase, followed by the restorative deep sleep phase, essential for physical recovery and growth. The cycle concludes with the Rapid Eye Movement (REM) phase, characterized by high brain activity and vivid dreaming. Insomnia, a prevalent sleep disorder, involves difficulty falling asleep, staying...
303
Prescription, Nonprescription and Orphan Drugs01:02

Prescription, Nonprescription and Orphan Drugs

Prescription drugs require a prescription from a medical practitioner and can only be obtained from a pharmacy. They have many applications, including treating pain, anxiety, and hypertension.
The misuse and addiction to prescription drugs is a growing problem that can affect people of all age groups, specifically teenagers. This can happen when prescription medications are used in ways not intended by the prescriber, such as taking someone else's prescription or using medication for...
818
Substance Use Disorders Affecting Sleep01:24

Substance Use Disorders Affecting Sleep

Substance use disorders involve a pattern of using drugs more extensively than intended and continuing use despite harmful consequences. This includes legal substances like alcohol and nicotine, as well as illegal drugs. These disorders often involve both physical and psychological dependence, reflecting compulsive use of substances that significantly alter thoughts, feelings, and behaviors, contributing to a major public health issue.
Understanding the concepts of physical dependence,...
205
Mania and Antimanic Drugs: Overview01:24

Mania and Antimanic Drugs: Overview

Mania, a psychological condition characterized by elevated mood, increased energy, and reduced sleep need, is part of the bipolar disorder cycle. The exact cause of mania isn't entirely known, but it is thought to be a combination of genetic, environmental, and neurological factors. Bipolar disorder involves alternating manic and depressive episodes. Mood stabilizers like lithium, antipsychotics, and anticonvulsants help manage these episodes. Lithium carbonate is particularly effective as...
290
Opioid Analgesics: Synthetic and Semisynthetic Opioids01:15

Opioid Analgesics: Synthetic and Semisynthetic Opioids

Synthetic and semisynthetic opioids are pivotal in pain management and tackling opioid addiction. Semisynthetic opioids, including morphinans (morphine derivatives), oxycodone, oxymorphone, hydrocodone, and hydromorphone, have improved pharmacokinetic profiles compared to morphine. Additionally, heroin and 6-MAM (6-Monoacetylmorphine) show better CNS penetration than morphine due to heightened lipid solubility. Hydromorphone, a potent opioid, undergoes hepatic metabolism to form the active...
373