Related Experiment Video
Updated: Aug 15, 2025

08:41
Live Imaging and Quantification of Viral Infection in K18 hACE2 Transgenic Mice Using Reporter-Expressing Recombinant SARS-CoV-2
Published on: November 5, 2021
2.9K
SARS-CoV-2 in brief: from virus to prevention
Hassan Karami1, Zeinab Karimi1, Negin Karami2
1Department of Virology, School of Public Health, Tehran University of Medical Sciences, Tehran, Iran.
Osong Public Health and Research Perspectives
|January 8, 2023
Summary
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is a highly transmissible virus that caused a global pandemic. This review covers SARS-CoV-2 characteristics, COVID-19, origins, and control strategies.
Area of Science:
- Virology
- Epidemiology
- Public Health
Background:
- The emergence of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has led to a global health crisis.
- The virus, with a probable zoonotic origin, rapidly spread worldwide, causing millions of fatalities.
Purpose of the Study:
- To provide essential information on the characteristics of SARS-CoV-2 and coronavirus disease 2019 (COVID-19).
- To briefly discuss the origins of the virus.
- To summarize strategies for controlling viral spread and transmission.
Main Methods:
- Literature review of scientific publications and reports.
- Synthesis of information on viral characteristics, disease, origin, and control measures.
Main Results:
- SARS-CoV-2 is a highly transmissible virus responsible for the COVID-19 pandemic.
- The virus likely originated in animals and spread globally despite containment efforts.
- Various strategies have been employed to mitigate viral transmission.
Conclusions:
- Understanding SARS-CoV-2 characteristics and transmission is crucial for pandemic management.
- Continued research into viral origins and effective control strategies remains vital.
- Global cooperation is essential to combat viral outbreaks.
Related Concept Videos
Infection
8.5K
When a pathogen enters the body and reproduces, it can cause an infection, damage body cells, and cause illness symptoms that eventually lead to disease. Therefore, its prevention requires breaking the chain of infection.
The chain begins with pathogens: bacteria, viruses, fungi, prions, or parasites such as protozoa helminths. These can be present on the skin as transient or resident flora, or they can be acquired from the environment. Identifying and treating the type of infection and...
The chain begins with pathogens: bacteria, viruses, fungi, prions, or parasites such as protozoa helminths. These can be present on the skin as transient or resident flora, or they can be acquired from the environment. Identifying and treating the type of infection and...
8.5K
Introduction to Virus
129
Viruses are unique biological entities that blur the boundary between living and non-living systems. Although they lack cellular structure and metabolic processes, they can exhibit characteristics of life when infecting a host. Their defining feature is a nucleic acid core, composed of either DNA or RNA, encapsulated within a protein coat called a capsid. This simple structure allows them to invade host cells and use their machinery for replication efficiently.Viral Structure and...
129
What are Viruses?
115.8K
Overview
115.8K
Viruses with RNA Genomes
79
RNA viruses are categorized into positive-strand, negative-strand, or double-stranded groups based on their genomic structure and replication mechanisms. This classification dictates how they exploit host cellular machinery for protein synthesis and replication. Some RNA viruses also utilize reverse transcription as part of their life cycle, further diversifying their replication strategies.Positive-Strand RNA VirusesPositive-strand RNA viruses have genomes that function directly as messenger...
79
Conjugated Proteins
18.4K
Simple proteins and protein complexes contain only amino acids. In contrast, many other proteins, called conjugated proteins, covalently bond with non-protein moieties.
Nucleoproteins are protein complexes that contain nucleic acids, categorized as deoxyribonucleoproteins (DNPs) or ribonucleoproteins (RNPs) respectively. The nucleosome is a typical example of a DNP where nuclear DNA is associated with histone proteins. The major antigen for the Covid-19 virus SARS-CoV is an RNP that is critical...
Nucleoproteins are protein complexes that contain nucleic acids, categorized as deoxyribonucleoproteins (DNPs) or ribonucleoproteins (RNPs) respectively. The nucleosome is a typical example of a DNP where nuclear DNA is associated with histone proteins. The major antigen for the Covid-19 virus SARS-CoV is an RNP that is critical...
18.4K
Viral Mutations
32.7K
A mutation is a change in the sequence of bases of DNA or RNA in a genome. Some mutations occur during replication of the genome due to errors made by the polymerase enzymes that replicate DNA or RNA. Unlike DNA polymerase, RNA polymerase is prone to errors because it is not capable of “proofreading” its work. Viruses with RNA-based genomes, like HIV, therefore accrue mutations faster than viruses with DNA-based genomes. Because mutation and recombination provide the raw material...
32.7K

