Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Essential Minerals for Bone Health01:31

Essential Minerals for Bone Health

4.2K
The minerals contained in all of the food we consume are essential for our organ systems. However, certain essential minerals, such as calcium, phosphorus, magnesium, manganese, and fluoride, largely affect bone health.
Calcium and Phosphorus
Calcium is a critical component of bones, especially in the form of calcium phosphate and calcium carbonate. Since the body cannot make calcium, it must be obtained from the diet. However, calcium cannot be absorbed from the small intestine without...
4.2K
Bone Disorders01:29

Bone Disorders

3.8K
Aging and its effect on bone remodeling is the most common cause of bone disorders. In young and healthy people, bone deposition and resorption happen at an equal rate to maintain optimal bone health.
Bone deposition is also affected by the levels of sex hormones like estrogen and testosterone that promote osteoblast activity and bone matrix synthesis. When the level of these hormones decreases due to aging, it causes a reduction in bone deposition. As a result, bone resorption by osteoclasts...
3.8K
Hormones and Bone Tissue01:17

Hormones and Bone Tissue

2.8K
The endocrine system produces and secretes hormones, which interact with the skeletal system. These hormones control bone growth, maintain bone once it is formed, and remodel it.
Hormones That Influence Osteoblasts and/or Maintain the Matrix
Several hormones are necessary for controlling bone growth and maintaining the bone matrix. The pituitary gland secretes growth hormone (GH), which, as its name implies, controls bone growth. This happens in several ways: first, it triggers chondrocyte...
2.8K
Role of Vitamins in Maintaining Bone Health01:25

Role of Vitamins in Maintaining Bone Health

3.5K
The growth and maintenance of bone are regulated by a combination of nutritional factors, including vitamins, such as vitamin A, B12, C, D, and K.
Vitamin A
Vitamin A is involved in the process of bone remodeling. Retinoic acid, the active metabolite of Vitamin A, has nuclear receptors in osteoblasts and osteoclasts, which are involved in bone remodeling.
Vitamin B12
Vitamin B12 acts as a cofactor during the formation of osteoblast-related proteins, such as osteocalcin. Vitamin B12 plays a role...
3.5K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Desert Hedgehog mediates stem Leydig cell differentiation through Ptch2/Gli1/Sf1 signaling axis.

eLife·2026
Same author

Biodegradable polylactic acid microplastics affect nutrient cycling during the entire crop growth cycle: Implications for soil ecosystem multifunctionality.

Environmental pollution (Barking, Essex : 1987)·2026
Same author

Dietary exposure to polystyrene microplastics impairs muscle growth via gut microbiota dysbiosis and hepatic oxidative stress along the gut-liver-muscle axis in Qihe gibel carp (Carassius gibelio var. Qihe).

Environmental pollution (Barking, Essex : 1987)·2026
Same author

Decellularized scaffolds of porcine uterus reconstruct the endometrial microenvironment to promote uterine epithelial cell differentiation and organoid formation.

Journal of materials chemistry. B·2026
Same author

Aptamer-functionalized apoptotic vesicles ameliorate osteoarthritis via resuming mitochondria OXPHOS of chondrocytes.

Science advances·2026
Same author

Unraveling Bridging-Oxygen-Driven Ultrafast Amorphization in Superionic Oxyhalide Conductors via in Situ Synchrotron X-Ray Scattering.

Angewandte Chemie (International ed. in English)·2026

Related Experiment Video

Updated: Aug 15, 2025

Cantilever Bending of Murine Femoral Necks
06:44

Cantilever Bending of Murine Femoral Necks

Published on: January 5, 2022

2.2K

D-Mannose prevents bone loss under weightlessness.

Ranli Gu1, Hao Liu2, Menglong Hu1

  • 1Department of Prosthodontics, National Clinical Research Center for Oral Diseases, National Engineering Laboratory for Digital and Material Technology of Stomatology, Beijing Key Laboratory of Digital Stomatology, Peking University School and Hospital of Stomatology, Beijing, 100081, China.

Journal of Translational Medicine
|January 8, 2023
PubMed
Summary

D-mannose, found in cranberries, prevents bone loss and urinary tract infections (UTIs) in rats experiencing weightlessness. It works by inhibiting osteoclast fusion, offering a potential solution for astronauts.

Keywords:
BoneCell fusionD-mannoseOsteoclastUTIWeightlessness

More Related Videos

Author Spotlight: Comparing Alveolar and Long Bone Remodeling to Explore OTM Model Potential
05:25

Author Spotlight: Comparing Alveolar and Long Bone Remodeling to Explore OTM Model Potential

Published on: July 21, 2023

1.5K
Exploring the Effects of Spaceflight on Mouse Physiology using the Open Access NASA GeneLab Platform
11:08

Exploring the Effects of Spaceflight on Mouse Physiology using the Open Access NASA GeneLab Platform

Published on: January 13, 2019

12.4K

Related Experiment Videos

Last Updated: Aug 15, 2025

Cantilever Bending of Murine Femoral Necks
06:44

Cantilever Bending of Murine Femoral Necks

Published on: January 5, 2022

2.2K
Author Spotlight: Comparing Alveolar and Long Bone Remodeling to Explore OTM Model Potential
05:25

Author Spotlight: Comparing Alveolar and Long Bone Remodeling to Explore OTM Model Potential

Published on: July 21, 2023

1.5K
Exploring the Effects of Spaceflight on Mouse Physiology using the Open Access NASA GeneLab Platform
11:08

Exploring the Effects of Spaceflight on Mouse Physiology using the Open Access NASA GeneLab Platform

Published on: January 13, 2019

12.4K

Area of Science:

  • Space Medicine
  • Biochemistry
  • Pharmacology

Background:

  • Microgravity-induced bone loss is a significant challenge for long-duration human spaceflight.
  • A safe, antiresorptive drug is needed to mitigate bone loss during space missions.
  • D-mannose, a natural sugar found in cranberries, is investigated for its potential bone-protective properties.

Purpose of the Study:

  • To investigate the protective effects of D-mannose against bone loss under simulated weightlessness.
  • To elucidate the underlying mechanisms of D-mannose's action on bone metabolism.
  • To assess D-mannose's impact on urinary tract infections (UTIs) associated with weightlessness.

Main Methods:

  • Tail-suspended (TS) rat model to simulate weightlessness.
  • Administration of D-mannose via intragastric gavage.
  • Analysis of bone mineral density, morphology, biomechanics, and serum markers.
  • In vitro studies on osteoclast and osteoblast function.
  • RNA-sequencing to identify molecular mechanisms.

Main Results:

  • TS rats exhibited reduced bone mineral density and poorer bone structure.
  • D-mannose treatment improved bone mineral density in TS rats.
  • D-mannose inhibited osteoclast proliferation and fusion, suppressing key fusion factors (DC-STAMP, c-Fos, NFATc1).
  • D-mannose also suppressed UTIs observed in TS rats.

Conclusions:

  • D-mannose effectively protects against bone loss and UTIs in a weightless rat model.
  • The bone-protective mechanism involves the inhibition of osteoclast cell fusion.
  • D-mannose presents a promising therapeutic strategy for mitigating health risks in space missions.