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Elevated renal nerve activity after spinal transection: effects on renal function.

J W Osborn1, R H Livingstone, L P Schramm

  • 1Department of Biomedical Engineering, Johns Hopkins University School of Medicine, Baltimore, Maryland 21205.

The American Journal of Physiology
|October 11, 1987
PubMed
Summary
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Spinal transection significantly increases renal sympathetic activity (RSA) in rats. This hyperactivity impacts renal function, but autoregulation of renal blood flow minimizes vascular changes.

Area of Science:

  • Neuroscience
  • Physiology
  • Renal Science

Background:

  • Spinal transection in rats leads to a doubling of renal sympathetic activity (RSA).
  • Understanding the spinal pathways controlling RSA and the consequences of this hyperactivity is crucial.

Purpose of the Study:

  • To identify spinal pathways that inhibit RSA.
  • To determine the impact of increased RSA on renal circulation and function post-transection.

Main Methods:

  • Experiments were performed on anesthetized, paralyzed, and artificially respired male Sprague-Dawley rats.
  • RSA was measured using electrodes on the renal nerve.
  • Renal arterial blood flow (RABF), glomerular filtration rate, urine flow, and electrolyte excretion were monitored.

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Main Results:

  • Lesions in the dorsal cervical spinal cord revealed descending pathways inhibiting RSA.
  • Autoregulation of RABF prevented increased RSA from altering renal vascular resistance.
  • Renal sodium and potassium excretion decreased significantly post-transection, with partial recovery when arterial pressure was maintained.

Conclusions:

  • Autoregulation effectively minimizes the vascular effects of elevated RSA after spinal transection.
  • Post-transection renal function changes are influenced by both altered arterial pressure and increased RSA.