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The optimal scaffold for silk sericin-based bone graft: collagen versus gelatin
Ji Hae Lee1, HaeYong Kweon1, Ji-Hyeon Oh2
1Sericultural and Apicultural Division, National Institute of Agricultural Science, RDA, Wanju, 55365, Republic of Korea.
Background:
Silk sericin is an active ingredient in bone grafts. However, the optimal scaffold for silk sericin has yet to be identified.
Method:
A critical-sized bone defect model in rat calvaria was used to evaluate bone regeneration. Silk sericin from Yeonnokjam, Bombyx mori, was incorporated into gelatin (group G, n = 6) and collagen (group C, n = 6). Bone regeneration was evaluated using micro-computed tomography (mCT) and histology.
Results:
Group C showed a larger bone volume than group G in the mCT analysis (P = 0.001). Histological analysis showed a larger area of bony defects in group G than in group C. The bone regeneration area in group C was significantly larger than that in group G (P = 0.003).
Conclusion:
Compared with gelatin, collagen shows better bone regeneration in silk sericin-based bone grafts.
