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Related Experiment Video

Updated: Aug 14, 2025

Utilization of Plasmonic and Photonic Crystal Nanostructures for Enhanced Micro- and Nanoparticle Manipulation
09:29

Utilization of Plasmonic and Photonic Crystal Nanostructures for Enhanced Micro- and Nanoparticle Manipulation

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A 3D Biocompatible Plasmonic Tweezer for Single Cell Manipulation.

Siyu Kang1,2, Muhammad Shemyal Nisar3, Yu Lu1,2

  • 1State Key Laboratory of Bioelectronics, School of Biological Science and Medical Engineering, Southeast University, Nanjing, 210096, China.

Small Methods
|January 9, 2023
PubMed
Summary

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This summary is machine-generated.

This study presents a novel 3D biocompatible plasmonic tweezer for precise single living cell manipulation. It utilizes a thermosensitive hydrogel for reversible cell binding, avoiding stress and enabling flexible transport.

Area of Science:

  • Biophysics
  • Nanotechnology
  • Cell Biology

Background:

  • Plasmonic tweezers offer low power, wide operating range for particle manipulation.
  • Trapping micron-sized objects, especially biological ones, remains a challenge for current plasmonic tweezers.

Purpose of the Study:

  • To develop a 3D biocompatible plasmonic tweezer for single living cell manipulation in solution.
  • To overcome limitations in trapping and manipulating larger biological objects with plasmonic tweezers.

Main Methods:

  • Designed a tapered tip with a three-layer structure: nanoprobe, gold nanofilm, and thermosensitive hydrogel (thiolated poly(N-isopropylacrylamide)).
  • Utilized incident light to excite surface plasmon polaritons, generating heat for hydrogel phase transition.
  • Enabled reversible cell binding via functionalized surface and cell membrane interaction, minimizing thermal and mechanical stress.
Keywords:
photothermal effectsplasmonic tweezerssingle cell manipulationsurface plasmon polaritonthermosensitive hydrogels

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Last Updated: Aug 14, 2025

Utilization of Plasmonic and Photonic Crystal Nanostructures for Enhanced Micro- and Nanoparticle Manipulation
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Main Results:

  • Achieved selective capture, 3D pathway-free transport, and controlled release of target cells.
  • Demonstrated excellent biocompatibility, low energy consumption, and high operational flexibility of the developed plasmonic tweezer.
  • Successfully manipulated single living cells in solution using the novel tweezer design.

Conclusions:

  • The 3D biocompatible plasmonic tweezer effectively addresses challenges in manipulating micron-sized biological objects.
  • This technology offers a promising tool for cell biology research and applications requiring precise cell handling.
  • The device exhibits superior biocompatibility and operational flexibility for advanced cell manipulation tasks.