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Longitudinal profile of circulating endothelial cells in post-acute coronary syndrome patients

Marie de Bakker1, Jaco Kraan2, K Martijn Akkerhuis1

  • 1Department of Cardiology, Erasmus MC, University Medical Center Rotterdam, Rotterdam, The Netherlands.

Biomarkers : Biochemical Indicators of Exposure, Response, and Susceptibility to Chemicals
|January 9, 2023
PubMed

Insights

Circulating endothelial cells (CECs) did not show increased levels before recurrent cardiac events in acute coronary syndrome (ACS) patients. This study suggests CECs may not predict secondary ACS events despite their link to vascular injury.

Area of Science:

  • Cardiovascular Medicine
  • Biomarker Research
  • Vascular Biology

Background:

  • Patients with acute coronary syndrome (ACS) face a risk of recurrent events, with varying individual risk levels.
  • Longitudinal measurements of circulating endothelial cells (CECs) show potential for improving risk assessment due to their temporal link with vascular injury.

Purpose of the Study:

  • To investigate whether longitudinal measurements of CECs can improve individual risk assessment for recurrent events in ACS patients.
  • To explore the predictive value of CEC concentrations prior to secondary adverse cardiac events.

Main Methods:

  • An explorative nested case-control study was conducted within the BIOMArCS multicenter observational study of 844 ACS patients.
  • High-frequency blood sampling was performed during 1-year follow-up after an index ACS.
  • CECs were quantified using flow cytometry in 15 cases with recurrent events and 30 matched controls.

Main Results:

  • Mean CEC concentration was persistently higher in cases than controls in the months preceding the recurrent event, but this difference was not statistically significant (P=0.339).
  • In controls, mean CEC concentration was significantly lower in samples collected >30 days post-ACS compared to samples collected within 1 day (P=0.030).
  • Similar trends were observed for CEC subsets expressing CD133/CD309 or CD106.

Conclusions:

  • Despite their association with vascular damage, increased CEC concentrations were not observed prior to the occurrence of secondary adverse cardiac events.
  • The study did not find evidence supporting the use of CEC levels as a predictor of recurrent cardiovascular events in ACS patients.

Keywords:
Circulating endothelial cellsacute coronary syndromeatherosclerosiscardiovascular diseaserepeated measurementsvascular injury

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