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Mucormycosis and aspergillosis: The deadly duo in COVID-19-a case report

Bijaya Mohanty1, Zeya Ansari1, Anil Prasad2

  • 1Department of Medicine, Jamshedpur, Jharkhand, India.

Journal of Family Medicine and Primary Care
|January 9, 2023
PubMed

Insights

This case report details a rare dual fungal infection (aspergillosis and mucormycosis) with a superadded bacterial infection in a COVID-19 patient. Aggressive treatment led to the patient's recovery and successful discharge.

Area of Science:

  • Infectious Diseases
  • Mycology
  • Critical Care Medicine

Background:

  • COVID-19 is linked to fungal infections like aspergillosis and mucormycosis, particularly in diabetic patients receiving steroids.
  • Co-infections with mucormycosis during COVID-19 outbreaks have been reported, but dual fungal and bacterial infections are uncommon.

Observation:

  • A patient with a severe COVID-19 infection developed a rare "fungal storm" involving both aspergillosis and mucormycosis.
  • The fungal infection was further complicated by a superadded bacterial infection with Klebsiella.

Findings:

  • The patient underwent aggressive treatment including antifungal agents, antibiotics, and surgical debridement.
  • Multimodal therapy resulted in the patient's improvement and eventual discharge after a prolonged hospital stay.

Implications:

  • This case highlights the potential for complex, polymicrobial infections in severe COVID-19 patients.
  • Prompt and aggressive management is crucial for improving outcomes in patients with severe COVID-19 and co-infections.
Keywords:
AspergillosisCOVID-19liposomal amphotericinmucormycosisposaconazole

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