Effect of Moringa oleifera Leaves against Hepatotoxicity Induced by Bisphenol A

Bisphenol A (BPA) is a synthetic compound with alterations in the liver, antioxidant enzymes, and reproductive hormones. The therapeutic potential of Moringa oleifera extract has recently been considered. The present study aimed to estimate the leaf extract of M. oleifera against hepatotoxicity induced by BPA. In total, 44 adult male rats were used in this study, and the experiment was conducted on 11 groups (4 animals per group). The rats were administrated (orally) with 5 and 10 mg/kg BPA and treated (orally) with 100, 200, 300, and 400 mg/kg of the aqueous extract of M. oleifera. After 28 days of challenge, liver enzymes, including aspartate transaminase (AST), alanine aminotransferase (ALT), and alkaline phosphatase (ALP), as well as a pathological study using the liver tissue sections were determined. The findings showed a significant (P≤0.05) increase in the AST, ALT, and ALP in the BPA groups with different histological changes that included the sclerosis of the bile duct surrounded by fibrocytes and lymphocytes infiltration. After treatment with M. oleifera, the liver enzymes and tissue returned to a normal state and showed non-significant (P≤0.05) differences, compared to the control group. According to the results, it can be concluded that the aqueous extract of M. oleifera has a great potential to prevent and improve liver damage of BPA.