Related Experiment Video
Updated: Aug 14, 2025

Basophil Activation Test for Allergy Diagnosis
Published on: May 31, 2021
Skin-homing basophils and beyond.
Rintaro Shibuya1,2,3, Brian S Kim1,2,4,5
1Kimberly and Eric J. Waldman Department of Dermatology, Icahn School of Medicine at Mount Sinai, New York City, NY, United States.
Skin-homing basophils, distinct from classical immune cells, exhibit unique characteristics. These findings offer new insights into epithelial barrier diseases and potential therapeutic targets.
Area of Science:
- Immunology
- Dermatology
- Cell Biology
Background:
- Basophils are implicated in type 2 inflammation and skin disorders like atopic dermatitis.
- Classical studies focused on hematopoietic basophils, overlooking tissue-specific roles.
Purpose of the Study:
- To highlight recent findings on skin-homing basophils.
- To explore their unique phenotype, function, and motility in barrier immunology.
Main Methods:
- Review of recent studies in barrier immunology.
- Analysis of basophil characteristics in skin tissues.
Main Results:
- Evidence suggests the existence of skin-homing basophils with distinct identities.
- These cells respond to unique developmental, chemotactic, and activation cues in the skin.
Conclusions:
- Skin-homing basophils possess unique properties influencing epithelial barrier immunity.
- Understanding these cells can inform therapeutic strategies for diseases involving epithelial surfaces.
More Related Videos
10:39Advanced Imaging of Lung Homing Human Lymphocytes in an Experimental In Vivo Model of Allergic Inflammation Based on Light-sheet Microscopy
Published on: April 16, 2019
05:58Preparation of Single-cell Suspensions for Cytofluorimetric Analysis from Different Mouse Skin Regions
Published on: April 20, 2016
Related Concept Videos
B Cell Activation and Differentiation
When naive B cells encounter a specific antigen that can bind to the B cell receptor (BCR) on their surface, they undergo sensitization to respond to the antigen's presence. Sensitization begins with...
Differentiation of Common Myeloid Progenitor Cells
Classification of Leukocytes
Neutrophils are the most abundant type of granular leukocytes, comprising 50-70% of all leukocytes. They feature small, evenly distributed granules and a...
Cells of the Innate Immune Response
Phagocytes
Phagocytes police the peripheral tissues by removing cellular debris and responding to the invasion of foreign substances or pathogens. Many phagocytes attack and remove microorganisms even before lymphocytes detect them. The human body has two general...
Inflammation
Immune Surveillance by NK Cells and Phagocytes
Natural Killer Cells: The Fast Responders
NK cells are large granular lymphocytes found in the blood and lymphatic system. These...