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Related Concept Videos

Pathophysiology of Diabetes01:20

Pathophysiology of Diabetes

1.1K
Diabetes mellitus is a chronic metabolic disorder characterized by hyperglycemia. The four categories of diabetes are type 1 diabetes, type 2 diabetes, other specific types of diabetes, and gestational diabetes.
Type 1 diabetes is characterized by autoimmune-mediated destruction of pancreatic β cells, with environmental factors potentially triggering this process in genetically susceptible individuals. Despite many not having a family history, certain genes increase susceptibility,...
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Diabetes Mellitus: Type 2 and Gestational01:22

Diabetes Mellitus: Type 2 and Gestational

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Type 2 diabetes, characterized by insulin resistance, arises when the insulin receptors on cells lose responsiveness to insulin, diminishing the cell's capacity to take up glucose, resulting in elevated blood glucose levels. To receive a diagnosis of Type 2 diabetes, a series of blood glucose tests are necessary to assess whether the blood glucose falls within normal parameters. If the result is out of the normal range, a patient may be diagnosed as prediabetic or diabetic, depending on the...
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Diabetes: Symptoms, Diagnosis, and Complications01:15

Diabetes: Symptoms, Diagnosis, and Complications

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For most patients, experiencing several weeks of polyuria, polydipsia, fatigue, and significant weight loss may indicate the presence of diabetes. Furthermore, adults displaying the phenotypic appearance of type 2 diabetes (particularly those who are obese and not initially insulin-requiring), may have islet cell autoantibodies, suggesting autoimmune-mediated β cell destruction and a diagnosis of latent autoimmune diabetes of adults (LADA). The categorization of glucose homeostasis is...
634

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Related Experiment Video

Updated: Aug 14, 2025

Author Spotlight: Studying the Impact of Maternal Dietary Deficiencies on Long-Term Offspring Health Outcomes
03:19

Author Spotlight: Studying the Impact of Maternal Dietary Deficiencies on Long-Term Offspring Health Outcomes

Published on: June 28, 2024

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Maternal Chromium Levels in Gestational Diabetes: Systematic Review and Meta-Analysis.

Akriti K Sharma1, Latika Mohan1, Sunita Mittal1

  • 1Department of Physiology, All India Institute of Medical Sciences AIIMS, Rishikesh, Uttarakhand, India.

Indian Journal of Endocrinology and Metabolism
|January 9, 2023
PubMed
Summary

Maternal chromium levels do not significantly differ between women with and without gestational diabetes mellitus (GDM). This systematic review found no conclusive link between chromium status and GDM, highlighting the need for further research.

Keywords:
Chromiumgestational diabetes mellitusmeta-analysissystematic review

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Area of Science:

  • Endocrinology
  • Nutritional Science
  • Reproductive Health

Background:

  • Maternal chromium (Cr) status in gestational diabetes mellitus (GDM) is debated, with conflicting findings on its association.
  • Previous studies show inconsistent results regarding chromium levels in GDM populations.

Purpose of the Study:

  • To systematically review and quantitatively synthesize existing research on the relationship between maternal chromium levels and GDM.
  • To resolve the controversy surrounding chromium status in pregnant women with GDM.

Main Methods:

  • A systematic review and meta-analysis adhering to PRISMA guidelines.
  • Inclusion of six studies for review and four for meta-analysis.
  • Utilized a random-effect model with a 95% confidence interval to compare pooled chromium values between control and GDM groups.

Main Results:

  • The meta-analysis revealed no statistically significant difference in pooled chromium levels between the control and GDM groups (P = 0.13).
  • High heterogeneity (I² = 97%) was observed across the included studies.
  • Subgroup analyses indicated variability based on study location, trimester, and chromium estimation technique.

Conclusions:

  • Current evidence does not support a significant difference in maternal chromium levels between women with and without GDM.
  • Factors like ethnicity, infection history, and diet may influence chromium status and GDM risk.
  • Further research is needed to clarify the role of chromium in GDM pathogenesis.