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A Web Tool for Generating High Quality Machine-readable Biological Pathways
Published on: February 8, 2017
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PathIN: an integrated tool for the visualization of pathway interaction networks.
George Minadakis1, Kyproula Christodoulou2, George Tsouloupas3
1Bioinformatics Department, The Cyprus Institute of Neurology & Genetics, 6 Iroon Avenue, 2371 Ayios Dometios, Nicosia, Cyprus | PO Box 23462, 1683, Nicosia, Cyprus.
Computational and Structural Biotechnology Journal
|January 9, 2023
Summary
PathIN is a web service for creating biological pathway networks from genes, compounds, and reactions. It aids in understanding molecular mechanisms linked to diseases using diverse network-building methods.
Area of Science:
- Bioinformatics
- Systems Biology
- Network Biology
Background:
- Understanding complex biological pathways is crucial for disease research.
- Existing tools may lack flexibility in network construction and data integration.
Purpose of the Study:
- To introduce PathIN, a web service for generating pathway-based networks.
- To provide a flexible platform for visualizing molecular mechanisms.
Main Methods:
- PathIN utilizes data from KEGG, Reactome, and Wiki Pathways.
- It offers five distinct methodologies for network construction, including direct and neighbor connections.
- The service supports network generation at gene, compound, and reaction levels.
Main Results:
- PathIN enables rapid creation of pathway networks across multiple species.
- The tool provides various network visualization options for biological insights.
- It integrates data from major pathway databases.
Conclusions:
- PathIN serves as a valuable reference tool for exploring disease-related molecular networks.
- The service facilitates a deeper understanding of biological systems through network analysis.
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