Developing a core outcome set (COS) for Dementia with Lewy bodies (DLB)

Area of Science:

• Neurology
• Gerontology
• Clinical Research Methodology

Background:

• Dementia with Lewy bodies (DLB) presents diverse symptoms (motor, neuropsychiatric, autonomic).
• DLB research is limited compared to Alzheimer's disease, with varied outcome measures hindering progress.
• A standardized Core Outcome Set (COS) is crucial for comparable and actionable DLB research.

Purpose of the Study:

• To develop a standardized Core Outcome Set (COS) for Dementia with Lewy bodies (DLB).
• To ensure consistent and relevant outcome measures in DLB treatment trials.
• To facilitate global comparison and implementation of DLB research findings.

Main Methods:

• Systematic review (PRISMA guidelines) for initial outcome identification.
• Multi-stage Delphi process involving diverse stakeholders (clinicians, patients, policymakers).
• Consensus meetings to finalize outcomes and select measurement instruments.

Main Results:

• The project aims to establish a definitive DLB-COS.
• Identification of appropriate instruments for measuring DLB-COS outcomes is a key objective.
• Global dissemination of the DLB-COS and associated instruments is planned.

Conclusions:

• The developed DLB-COS will standardize outcome selection in treatment trials.
• This initiative will enhance the comparability and utility of DLB research worldwide.
• The project addresses a critical need for consistent methodology in DLB research and clinical practice.