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Updated: Aug 14, 2025

Evidence-based Knowledge Synthesis and Hypothesis Validation: Navigating Biomedical Knowledge Bases via Explainable AI and Agentic Systems
Published on: June 13, 2025
Methodology for development of an expert system to derive knowledge from existing nature-based solutions experiences
Shahryar Sarabi1, Qi Han1, Bauke de Vries1
1Information Systems in the Built Environment (ISBE) Group, Department of Built Environment, Eindhoven University of Technology, Groene Loper 3, 5612 AE Eindhoven, Netherlands.
Abstract:
Learning from past experiences is essential for the adoption of Nature-Based Solutions (NBS). There is a growing number of knowledge repositories sharing the experience of NBS projects implemented worldwide. These repositories provide access to a large amount of information, however, acquiring knowledge from them remains a challenge. This paper outlines the technical details of the NBS Case-Based System (NBS-CBS), an expert system that facilitates knowledge acquisition from an NBS case repository. The NBS-CBS is a hybrid system integrating a black-box Artificial Neural Network (ANN) with a white-box Case-Based Reasoning model. The system involves:•a repository that stores the information of past NBS projects, and an input collection component, guiding the collection and encoding of the user's inputs;•a classifier that predicts solutions (i.e., generates a hypothesis), based on user input (target case), drawing on a pre-trained ANN model to guide the case retrieval, and a case retrieval engine that identifies cases similar to the target case;•a case adaption and retainment process in which the user assesses the provided recommendations and retains the solved problem as a new case in the repository.
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