Related Experiment Video
Updated: Aug 14, 2025
10:54
Extraction of Plant-based Capsules for Microencapsulation Applications
Published on: November 9, 2016
12.1K
A developed composite hard-gelatin capsules: delayed-release enteric properties.
Mozhgan Nezhad Mohseni1, Ghasem Najafpour Darzi2, Ramin Ramezani2
1Mazandaran Institute of Technology, Babol, 61136-47481, Iran.
Heliyon
|January 9, 2023
Summary
This study developed novel delayed-release hard gelatin capsules using gastric acid-resistant polymers. These improved capsules protect sensitive drugs in the stomach, enhancing intestinal absorption.
Area of Science:
- Pharmaceutical Sciences
- Drug Delivery Systems
Background:
- Conventional hard gelatin capsules offer immediate drug release.
- Sensitive drugs require protection from gastric acid for optimal absorption.
- Gastric acid-resistant polymers can modify capsule release profiles.
Purpose of the Study:
- To develop novel delayed-release hard gelatin capsules.
- To investigate the impact of specific intestinal polymers on drug release.
- To enhance the absorption of acid-sensitive drugs.
Main Methods:
- Formulation of hard gelatin capsules incorporating gastric acid-resistant polymers.
- Inclusion of intestinal polymers: Hydroxy propyl methyl cellulose phthalate, Glucomannan, and Polyvinyl alcohol.
- Evaluation of capsule release rates and degradation in acidic environments.
Main Results:
- Delayed-release capsules exhibited minimal drug release in acidic stomach conditions.
- Capsule shells remained intact in the stomach and dissolved in the intestine.
- Formulation modifications with enteric polymers successfully imparted delayed-release properties.
Conclusions:
- Modified hard gelatin capsules demonstrate effective delayed-release characteristics.
- Enteric polymers, through formulation changes, enable targeted intestinal drug delivery.
- This approach improves the delivery and absorption of drugs sensitive to gastric conditions.
Related Concept Videos
01:18Drug Delivery: Enteral Route
579
The enteral drug administration involves three primary routes: oral, sublingual, and buccal. Oral ingestion is the most prevalent, safe, economical, and convenient method for drug administration. However, it has certain drawbacks, including limited absorption due to the drug's low water solubility or poor membrane permeability, possible emesis from GI mucosa irritation, destruction of drugs by digestive enzymes or low gastric pH, and irregular absorption along with food or other drugs.
579
01:18Routes of Drug Administration: Enteral
4.0K
Medications can be administered through the enteral route using liquids, capsules, or tablets.
Enteral administration involves drug administration via the mouth in two ways: orally or sublingually.
Unlike sublingually drugs, drugs that are taken orally pass through the gastrointestinal (GI) tract and get metabolized by the liver. Once metabolized, the drug is absorbed into the systemic circulation, reaching different body parts via the bloodstream. However, while passing through the stomach,...
Enteral administration involves drug administration via the mouth in two ways: orally or sublingually.
Unlike sublingually drugs, drugs that are taken orally pass through the gastrointestinal (GI) tract and get metabolized by the liver. Once metabolized, the drug is absorbed into the systemic circulation, reaching different body parts via the bloodstream. However, while passing through the stomach,...
4.0K