Acrofacial necrotic ulcers in an infant: An undiagnosed presentation

Georgina-Maria Sarika1, Rony Shreberk-Hassidim1, Alexander Maly2

  • 1Department of Dermatology.

Frontiers in Pediatrics
|January 9, 2023
PubMed

Insights

This case study describes a child with severe skin ulcers, worsening in cold weather. Researchers hypothesize it may be a new autoinflammatory disease, as current tests are inconclusive.

Area of Science:

  • Pediatric dermatology
  • Immunology
  • Genetics

Background:

  • Acral necrotic ulcers in infancy are rare.
  • These ulcers have been associated with type I interferonopathies.
  • Autoinflammatory diseases can present with diverse and severe symptoms.